The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle.
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle.
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DOI：
10.1016/j.ijpara.2016.10.002
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发表时间：
2017-06
影响因子：
4
通讯作者：
Kappe SHI
中科院分区：
文献类型：
--
作者：
Arredondo SA;Kappe SHI
在其生命周期中，疟原虫依赖于大量蛋白质，这些蛋白质与宿主或媒介建立关键的相互作用，并在寄生虫的有性阶段之间建立关键的相互作用，以确保感染、繁殖和增殖。其中有一组分泌型或膜锚定蛋白，称为6-半胱氨酸(6-Cys)家族。这是一个小但重要的家庭，到目前为止只有14个成员被确认，每个阶段--特别是在寄生虫的生命周期中表达。6-CyS蛋白通常定位于寄生虫的表面或与宿主的界面，在不同的疟原虫物种中保守。该家族的统一特征是s48/45结构域，推测该结构域参与黏附，并在结构上与EphR的配体--肾上腺素相关。最突出的s48/45成员目前正在接受功能调查，并正在作为候选疫苗进行追踪。本文综述了6-cys家族的结构和功能，并讨论了未来的研究方向。
During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host or vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family. This is a small but important family with only 14 members thus far identified, each stage-specifically expressed during the parasite life cycle. 6-cys proteins often localize at the parasite surface or interface with the host and are conserved in different Plasmodium species. The unifying feature of the family is the s48/45 domain, presumably involved in adhesion and structurally related to Ephrins, the ligands of Eph receptors. The most prominent s48/45 members are currently under functional investigation and are being pursued as vaccine candidates. In this review, we examine what is known about the 6-cys family, their structure and function, and discuss future research directions.