Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters
Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters
复制标题
钴肟催化无酸性促进剂的末端炔烃水合
DOI：
10.1039/c7cc03919k
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发表时间：
2017-06-28
影响因子：
4.9
通讯作者：
Li, Yun
中科院分区：
文献类型：
--
作者：
Hou, Shengtai;Yang, Hongjian;Li, Yun
钴肟 (Co(dmgBF(2))(2) 中心点 2H(2)O) 是一种廉价的第一行过渡金属络合物，催化末端炔烃的水合在中性条件下以良好至优异的产率生成相应的甲基酮（不需要额外的质子酸和银盐）。可以耐受多种官能团，例如烯丙基醚、苄基醚、羧酸酯、酰亚胺、酰胺、硝基和卤素。温和的反应条件以及催化剂的廉价和易获得性很好地解决了当前炔烃水合领域的挑战。
Cobaloxime (Co(dmgBF(2))(2)center dot 2H(2)O), an inexpensive first-row transition-metal complex, catalyzed hydration of terminal alkynes gave the corresponding methyl ketones in good to excellent yields under neutral conditions (additional protic acids and silver salts are not required). A wide range of functional groups, such as allyl ether, benzyl ethers, carboxylic esters, imides, amides, nitro, and halogens, were tolerated. The mild reaction conditions together with the inexpensive feature and easy availability of the catalyst well address the current challenges in the field of alkyne hydration.