HIGH-LEVELS OF VIRAL REPLICATION DURING ACUTE HEPATITIS-B INFECTION PREDICT PROGRESSION TO CHRONICITY
HIGH-LEVELS OF VIRAL REPLICATION DURING ACUTE HEPATITIS-B INFECTION PREDICT PROGRESSION TO CHRONICITY
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DOI：
10.1002/jmv.1890430210
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发表时间：
1994-06-01
影响因子：
12.7
通讯作者：
HOOFNAGLE, JH
中科院分区：
文献类型：
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作者：
FONG, TL;DIBISCEGLIE, AM;HOOFNAGLE, JH
为探讨急性乙肝时血清标志物的演变规律，对20世纪50年代在实验研究中先后采集的12例乙肝病毒感染者的血清标本进行了HBs-Ag、HBeAg和HBVDNA检测。6名患者发展为急性自限性肝炎，3名患者发展为慢性肝炎，3名患者在无乙肝表面抗原的情况下无症状感染。HBs Ag是第一个检测到的血清学指标(平均为暴露后52天)，其次是HBeAg(62天)和HBVDNA(72天)。HBs Ag峰值出现在症状出现前，且与HBeAg、HBVDNA峰值滴度相关。慢性肝炎患者的病毒标志物峰值水平高于自限性疾病患者：HBs Ag(30对5.4 mU g/ml)、HBeAg(1：2000对1：60滴度)和HBVDNA(3,192对444 pg/ml)。因此，慢性乙肝病毒感染的特征是在感染的急性期早期出现高水平的病毒复制。(C)1994年Wiley-Liss，Inc.*
To assess the pattern of development of sero9logic markers during acute hepatitis B, levels of HBsAg, HBeAg, and hepatitis B virus (HBV) DNA were assayed in stored serum samples obtained sequentially from 12 subjects infected with HBV during experimental studies conducted in the 1950s. Six patients developed acute self-limited hepatitis, three developed chronic hepatitis, and three had an asymptomatic infection with out HBsAg. HBsAg was the first serologic marker detected (mean = 52 days after exposure), followed by HBeAg (62 days) and HBV DNA (72 days). Peak HBsAg levels occurred before onset of symptoms and correlated with peak titers of HBeAg and HBV DNA. Patients who developed chronic hepatitis had higher peak levels of viral markers than those with self-limited disease: HBsAg (30 versus 5.4 mu g/ml), HBeAg (1:2,000 versus 1:60 titer) and HBV DNA (3,192 versus 444 pg/ml). Thus, chronic HBV infection is characterized by high levels of viral replication appearing early during the acute phase of infection. (C) 1994 Wiley-Liss, Inc.*