Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo
Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo
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DOI：
10.1016/j.neulet.2004.06.072
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发表时间：
2004-09-23
影响因子：
2.5
通讯作者：
Shibata, S
中科院分区：
文献类型：
--
作者：
Horikawa, K;Shibata, S
一些证据表明，5-HT神经元系统可能发挥了至关重要的作用，非光夹带的啮齿动物昼夜节律钟。虽然已经确定5-HT 1A/7受体激动剂（+）8-羟基-2-（二正丙基氨基）四氢萘[（+）8-OH-DPAT]可引起仓鼠行为节律的相位提前，但对该药物是否引起小鼠活动节律的相位偏移知之甚少。因此，我们研究了（+）8-OH-DPAT对小鼠自发活动节律的影响。在主观白天中期全身给予该化学品可诱导明显的剂量依赖性相位提前，而在其他时间（主观白天早期、主观白天晚期或主观夜晚）无显著相位偏移。此外，（+）8-OH-DPAT加速了小鼠行为节律的再诱导，使其提前6小时进入光暗周期。这些结果表明，我们可以使用小鼠来了解（+）8-OH-DPAT诱导的相移的分子机制，因为时钟基因靶向小鼠的可用性。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Several lines of evidence indicate that 5-HT neuronal systems may play a critical role for the non-photic entrainment of the rodent circadian clock. Although it is well established that (+)8-hydroxy-2-(di-n-propylamino)tetralin [(+)8-OH-DPAT], a 5-HT1A/7 receptor agonist, causes a phase-advance of behavioral rhythm in hamsters, little is known whether this agent produces phase shifts of activity rhythm in mice. Therefore, we examined the effect of (+)8-OH-DPAT on the mouse locomotor activity rhythm. Systemic administration of this chemical at mid-subjective daytime induced a clear and dose-dependent phase advance, while there were no significant phase shifts at other times (early-subjective day, late-subjective day, or subjective night). Additionally, (+)8-OH-DPAT accelerated the re-entrainment of mouse behavioral rhythm to a 6-h advanced light-dark cycle. These results suggest that we can use mice for understanding the molecular mechanism of (+)8-OH-DPAT-induced phase shift because of availability of clock gene targeted mice. (C) 2004 Elsevier Ireland Ltd. All rights reserved.