Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)
Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)
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DOI：
10.1039/c1cc16077j
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Thurecht, Kristofer J.
中科院分区：
文献类型：
--
作者：
Muennemann, Kerstin;Koelzer, Michael;Thurecht, Kristofer J.
第一次使用对氢诱导极化(PhIP)的聚合物超极化是通过生物相容的超支化聚合物中末端炔基的氢化而被报道的。根据聚合物的结构，可以获得1500倍的信号增强，从而为聚合物分子成像开辟了新的潜在途径。
The first hyperpolarisation of polymers using parahydrogen induced polarisation (PHIP) is reported by hydrogenation of terminal alkyne groups in a biocompatible hyperbranched polymer. Signal enhancements of 1500-fold could be obtained depending on the structure of the polymer, thus opening new potential avenues for polymeric molecular imaging.