SELECTIVE FOREBRAIN FIBER TRACT LESIONS IMPLICATE VENTRAL HIPPOCAMPAL STRUCTURES IN TONIC REGULATION OF PARAVENTRICULAR NUCLEUS CORTICOTROPIN-RELEASING HORMONE (CRH) AND ARGININE VASOPRESSIN (AVP) MESSENGER-RNA EXPRESSION
SELECTIVE FOREBRAIN FIBER TRACT LESIONS IMPLICATE VENTRAL HIPPOCAMPAL STRUCTURES IN TONIC REGULATION OF PARAVENTRICULAR NUCLEUS CORTICOTROPIN-RELEASING HORMONE (CRH) AND ARGININE VASOPRESSIN (AVP) MESSENGER-RNA EXPRESSION
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DOI：
10.1016/0006-8993(92)91680-d
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发表时间：
1992-10-02
期刊：
影响因子：
2.9
通讯作者：
WATSON, SJ
中科院分区：
文献类型：
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作者：
HERMAN, JP;CULLINAN, WE;WATSON, SJ
海马似乎通过与下丘脑室旁核 (PVN) 的促肾上腺皮质激素释放激素 (CRH) 和含有精氨酸加压素 (AVP) 的神经元相互作用，参与下丘脑 - 垂体 - 肾上腺皮质轴的强直调节。为了进一步研究这种相互作用的解剖学基础，对前脑纤维束进行损伤，以将抑制信息从海马体传递到 PVN。通过半定量原位杂交组织化学检测，穹窿伞部总横断 (TFF) 和穹窿外侧伞部损伤 (LFF) 均显着增加内侧细小细胞 PVN 中的 CRH mRNA 水平。内侧穹窿伞部病变或内侧皮质下丘脑束 (MCHT) 部分不影响 CRH mRNA 水平。 LFF 组显示 AVP mRNA 和 ACTH 分泌均增加，而其他病变在这方面没有效果。结果表明； (1) 海马传出神经对 HPA 轴产生强直性抑制，可能起源于穹窿横向范围的区域，代表 CA1 腹侧下托和腹侧范围的结构； (2) 从海马到下丘脑基底内侧的投射（在 MCHT 中移动）不太可能影响 HPA 功能； (3)海马可能在多个水平上影响PVN CRH/AVP神经元，LFF和TFF病变对PVN AVP mRNA水平和ACTH分泌有不同的影响。
The hippocampus appears to be involved in tonic regulation of the hypothalamo-pituitary-adrenocortical axis via interactions with corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP)-containing neurons of the hypothalamic paraventricular nucleus (PVN). To further investigate the anatomical basis of such interactions, lesions were made to forebrain fiber tracts in position to communicate inhibitory information from the hippocampus to the PVN. Total fimbria-fornix transections (TFF) and lateral fimbria-fornix lesions (LFF) both significantly increased CRH mRNA levels in the medial parvocellular PVN, as assayed by semi-quantitative in situ hybridization histochemistry. Medial fimbria-fornix lesions or section of the medial corticohypothalamic tracts (MCHT) did not influence CRH mRNA levels. The LFF group showed increases in both AVP mRNA and ACTH secretion, whereas no other lesion was effective in this regard. The results suggest; (1) hippocampal efferents confering tonic inhibition of the HPA axis probably originate in regions contributing to the lateral extent of the fornix, representing structures in the ventral subiculum and ventral extent of CA1; (2) projections from the hippocampus to the medial basal hypothalamus (travelling in the MCHT) are unlikely to affect HPA function; (3) hippocampus may influence the PVN CRH/AVP neuron at multiple levels, in that LFF and TFF lesions have differential effects on PVN AVP mRNA levels and ACTH secretion.