Axonal potassium conductance and glycemic control in human diabetic nerves
Axonal potassium conductance and glycemic control in human diabetic nerves
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DOI：
10.1016/j.clinph.2004.12.019
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发表时间：
2005-05-01
影响因子：
4.7
通讯作者：
Hattori, T
中科院分区：
文献类型：
--
作者：
Misawa, S;Kuwabara, S;Hattori, T
目的：探讨高血糖对轴突兴奋性和钾电导在人类糖尿病nerves.Methods：阈值跟踪测量兴奋性指数，这取决于钾通道（超常，晚亚正常，阈值电紧张，和电流/阈值的关系）在正中运动轴突的96例糖尿病患者。结果：在糖尿病患者中，较高的血清血红蛋白A1 c（HbA 1c）水平与较大的超正常（P=0.04）和较小的晚期亚正常（P=0.02）显著相关，提示高血糖时结/旁结钾电流降低。阈值电紧张性和电流/阈值关系与HbA 1c水平无关，但部分与神经传导减慢有关。结论：高血压可降低结钾电导，可能是由于降低膜钾梯度或抑制钾通道。与此相反，结间钾电导可能是由代谢因素和结构变化，如暴露的结间通道由demyelination.Significance：兴奋性指数的测量可以提供新的见解，在人类糖尿病神经病变的节点和结间轴突膜的属性，而多种因素可以影响，特别是结间的属性。(c)2005年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有战斗。
Objective: To investigate the effects of hyperglycemia on axonal excitability and potassium conductance in human diabetic nerves.Methods: Threshold tracking was used to measure excitability indices, which depend on potassium channels (supernormality, late subnormality, threshold electrotonus, and a current/threshold relationship) in median motor axons of 96 diabetic patients. The effects of hyperglycemia on these indices were analyzed.Results: Among diabetic patients, higher serum hemoglobin Ale (HbA1c) levels were significantly associated with greater supernormality (P=0.04) and smaller late subnormality (P=0.02), suggestive of reduced nodal/paranodal potassium currents under hyperglycemia. Threshold electrotonus and current/threshold relationships did not correlate with HbA1c levels, but partly related with nerve conduction slowing.Conclusions: Hyperglycemia could reduce nodal potassium conductances, possibly due to reduced membranous potassium gradient or suppression of potassium channels. In contrast, internodal potassium conductances may be determined by both metabolic factors and structural changes such as exposure of internodal channels by demyelination.Significance: Measurements of the excitability indices could provide new insights into nodal and internodal axonal membrane properties in human diabetic neuropathy, whereas multiple factors can affect especially internodal properties. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All fights reserved.