INSULIN ELICITS INGESTION IN DECEREBRATE RATS
INSULIN ELICITS INGESTION IN DECEREBRATE RATS
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DOI：
10.1126/science.6344221
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
GRILL, HJ
中科院分区：
文献类型：
--
作者：
FLYNN, FW;GRILL, HJ
给大鼠注射胰岛素能可靠地促进摄食。为了确定是否神经机制足以控制胰岛素引起的摄入位于或尾部前脑，去大脑大鼠用胰岛素治疗和摄食反应进行了测量。在对照组和去大脑大鼠中，胰岛素治疗产生的低血糖在幅度和持续时间上相当。去脑大鼠和对照组大鼠在低血糖时比正常血糖时摄入更多的蔗糖溶液。相比之下，胰岛素并没有增加两组的饮水量。前脑尾侧的神经系统足以通过整合胰岛素治疗产生的代谢信号和口咽部的味觉传入输入来控制摄食消费行为。
Insulin administered to rats reliably elicits ingestion of food. To determine whether the neural mechanisms sufficient to control insulin-elicited ingestion are located in or caudal to the forebrain, decerebrate rats were treated with insulin and ingestive responses were measured. Insulin treatment produced hypoglycemia that was comparable, in magnitude and duration, in control and decerebrate rats. Decerebrate and control rats ingested significantly more sucrose solution while hypoglycemic than while normoglycemic. In contrast, insulin did not augment the water consumption of either group. Neural systems caudal to the forebrain are sufficient to control ingestive consummatory behavior through the integration of metabolic signals generated by insulin treatment and taste afferent input from the oropharynx.