Network stability from activity-dependent regulation of neuronal conductances
Network stability from activity-dependent regulation of neuronal conductances
复制标题
DOI：
10.1162/089976699300016359
复制
发表时间：
1999-07-01
影响因子：
2.9
通讯作者：
Marder, E
中科院分区：
文献类型：
--
作者：
Golowasch, J;Casey, M;Marder, E
活动依赖的可塑性似乎在发育和学习过程中发生的神经元和神经回路的修改中起着重要作用。在面对多变的环境和内部条件时，可塑性对于维持稳定的活动模式也是必不可少的。先前的理论和实验结果表明，神经元通过改变离子通道的数量或特征来调节其固有的电学特性，从而稳定其活动。我们提出了实验和模型证据，表明活动依赖的电导调节，在单个神经元水平上运作，也可以稳定网络活动。这些结果表明，螃蟹的口胃神经节在两种完全不同的操作模式下可以产生一种特有的节律性活动模式。在一种模式下，节律严格依赖于邻近神经节的神经调节传入。另一方面，它独立于神经调节输入，但依赖于新发展的神经元组成部分的内在特性。
Activity-dependent plasticity appears to play an important role in the modification of neurons and neural circuits that occurs during development and learning. Plasticity is also essential for the maintenance of stable patterns of activity in the face of variable environmental and internal conditions. Previous theoretical and experimental results suggest that neurons stabilize their activity by altering the number or characteristics of ion channels to regulate their intrinsic electrical properties. We present both experimental and modeling evidence to show that activity-dependent regulation of conductances, operating at the level of individual neurons, can also stabilize network activity. These results indicate that the stomatogastric ganglion of the crab can generate a characteristic rhythmic pattern of activity in two fundamentally different modes of operation. In one mode, the rhythm is strictly conditional on the presence of neuromodulatory afferents from adjacent ganglia. In the other, it is independent of neuromodulatory input but relies on newly developed intrinsic properties of the component neurons.