Structural brain changes in tinnitus
Structural brain changes in tinnitus
复制标题
DOI：
10.1093/cercor/bhj070
复制
发表时间：
2006-09-01
期刊：
影响因子：
3.7
通讯作者：
Sander, D.
中科院分区：
文献类型：
--
作者：
Muehlau, M.;Rauschecker, J. P.;Sander, D.
耳鸣是一种常见但知之甚少的疾病，其特征是耳朵中的铃声或嗡嗡声。中枢机制必须在产生这种听觉幻感觉中起关键作用，因为在大多数情况下，切断听觉神经后，这种感觉仍然存在。耳鸣是由听觉皮层中的音调映射图的重组引起的，这导致耳鸣频率的过度表示。此外，已经假设边缘系统参与产生耳鸣。在这里，我们的目的是确定大脑区域显示耳鸣的结构变化。我们使用高分辨率磁共振成像和基于体素的形态测量法对耳鸣患者和健康对照组进行了比较。在听觉通路中，我们发现灰质只在丘脑水平增加。在听觉系统外，胼胝体下区（包括延髓核）的灰质减少。我们的研究结果表明，相互参与的感觉和情感领域是必不可少的产生耳鸣。
Tinnitus is a common but poorly understood disorder characterized by ringing or buzzing in the ear. Central mechanisms must play a crucial role in generating this auditory phantom sensation as it persists in most cases after severing the auditory nerve. One hypothesis states that tinnitus is caused by a reorganization of tonotopic maps in the auditory cortex, which leads to an over-representation of tinnitus frequencies. Moreover, the participation of the limbic system in generating tinnitus has been postulated. Here we aimed at identifying brain areas that display structural change in tinnitus. We compared tinnitus sufferers with healthy controls by using high-resolution magnetic resonance imaging and voxel-based morphometry. Within the auditory pathways, we found gray-matter increases only at the thalamic level. Outside the auditory system, gray-matter decrease was found in the subcallosal region including the nucleus accumbens. Our results suggest that reciprocal involvement of both sensory and emotional areas are essential in the generation of tinnitus.