High-performance neuroprosthetic control by an individual with tetraplegia.
High-performance neuroprosthetic control by an individual with tetraplegia.
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DOI：
10.1016/s0140-6736(12)61816-9
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发表时间：
2013-02-16
期刊：
影响因子：
168.9
通讯作者：
Schwartz, Andrew B.
中科院分区：
文献类型：
--
作者：
Collinger, Jennifer L.;Wodlinger, Brian;Downey, John E.;Wang, Wei;Tyler-Kabara, Elizabeth C.;Weber, Douglas J.;McMorland, Angus J. C.;Velliste, Meel;Boninger, Michael L.;Schwartz, Andrew B.
我们用手臂来运输和定向用来抓取和操纵物体的手。上肢瘫痪或截肢限制了一个人与环境互动以完成日常生活活动的能力。脑机接口（BMIs）可以提供一种解决方案来恢复大部分功能。将两个96通道皮质内微电极植入四肢瘫痪患者的运动皮质。进行了13周的BMI训练，目标是控制具有7个自由度（3D平移、3D定向、1D抓取）的拟人假肢。上肢功能的临床测量用于评估参与者使用假肢的能力。在培训的第二天，参与者展示了在三维（3D）工作空间中自由移动器械的能力。13周后，常规进行稳健的7自由度运动。随着时间的推移，基于目标的到达任务的性能在成功率、完成时间和路径效率方面有所改善。参与者还能够使用假肢进行熟练和协调的伸展和抓握运动，从而在上肢功能测试中获得临床显著收益。这项研究表明，一个患有慢性四肢瘫痪的人可以用拟人机器人手臂进行一致，自然和复杂的运动，以恢复临床上重要的功能。国防高级研究计划局、国立卫生研究院、退伍军人事务部和UPMC康复研究所
We use our arms to transport and orient the hand which is used to grasp and manipulate objects. Upper limb paralysis or amputation limits a person’s ability to interact with their environment to accomplish activities of daily living. Brain-machine interfaces (BMIs) may provide a solution to restoring much of this function. Two 96-channel intracortical microelectrodes were implanted in the motor cortex of an individual with tetraplegia. Thirteen weeks of BMI training were conducted with the goal of controlling an anthropomorphic prosthetic limb with 7 degrees-of-freedom (3D translation, 3D orientation, 1D grasping). Clinical measures of upper-limb function were used to assess the participant’s ability to use the prosthetic limb. The participant demonstrated the ability to move the device freely in the three-dimensional (3D) workspace on the second day of training. After 13 weeks, robust 7 degree-of-freedom movements were performed routinely. Over time, performance on target-based reaching tasks improved in terms of success rate, completion time, and path efficiency. The participant was also able to use the prosthetic limb to perform skillful and coordinated reach and grasp movements that resulted in clinically significant gains in tests of upper-limb function. This study demonstrates that a person with chronic tetraplegia can perform consistent, natural, and complex movements with an anthropomorphic robotic arm to regain clinically significant function. Defense Advanced Research Projects Agency, National Institutes of Health, Department of Veterans Affairs, and UPMC Rehabilitation Institute