Age and gender specific lung function predictive equations provide similar predictions for both a twin population and a general population from age 6 through adolescence.
Age and gender specific lung function predictive equations provide similar predictions for both a twin population and a general population from age 6 through adolescence.
复制标题
年龄和性别特定的肺功能预测方程为双胞胎人群和 6 岁至青春期的一般人群提供了类似的预测。
DOI：
10.1002/ppul.20631
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发表时间：
2007
影响因子：
3.1
通讯作者：
Wang,Xiaobin
中科院分区：
文献类型：
--
作者：
Yu,Yunxian;Kumar,Rajesh;Venners,Scott;Pongracic,Jacqueline;Wang,Binyan;Yang,Jianhua;Li,Zhiping;Wang,Liuliu;Liu,Xue;Tang,Genfu;Xing,Houxun;Xu,Xiping;Wang,Xiaobin
已有大量关于双胞胎哮喘的研究，但没有研究评估肺功能预测模型是否在双胞胎和普通人群中产生相似的结果。我们试图在儿童晚期和青少年受试者中评估这一点。方法：在3140名健康、不吸烟的中国双胞胎的社区队列中，我们使用广义估计方程来调整双胞胎之间的相关性，建立了FEV1和FVC的横截面、性别和年龄特异性回归模型。我们将该模型应用于来自同一地区的2187名健康非吸烟普通人群队列，并比较了两个人群的预测fev1和FVC值。结果身高与fev1或FVC的相关性在年龄和性别上存在差异。在青春期生长高峰期（女孩为13岁，男孩为14 - 16岁），身高与fev1或FVC的关系是非线性的，且大于其他年龄段。在青春期，同一身高的fev1和FVC随年龄增长而增加。双胞胎群体fev1和FVC的百分比预测值与一般人群相似。结论儿童与普通人群在儿童中期和青少年期肺功能变化模式相似。类似的方程可以用来估计百分比预测值。最后，由于青春期相关的变化，单一的预测方程不能完全描述从童年到青春期的肺功能模式。儿科肺科杂志2007；42:631 - 639。©2007 Wiley‐Liss, Inc。
BackgroundThere have been numerous studies of asthma in twins, but no study has evaluated whether lung function predictive models yield similar results between twin and general populations. We sought to evaluate this in late childhood and adolescent subjects.MethodsWe generated cross‐sectional, sex‐ and age‐specific regression models of FEV1, and FVC, in a community‐based cohort of 3140 healthy, non‐smoking Chinese twins using generalized estimating equations to adjust for correlations within twin pairs. We applied the model to a healthy non‐smoking general population cohort of 2187 subjects from the same region, and compared %predicted FEV1and FVC values between the two populations.ResultsStratified by age and sex, the associations of height with FEV1or FVC varied by age group. During the adolescent growth spurt (age 13 for girls and ages 14‐16 for boys), the associations of height with FEV1or FVC were nonlinear and greater than that seen at other ages. During adolescence, FEV1and FVC for a given height increased with age. The percent predicted values of FEV1and FVC in the twin population were similar to that of the general population.ConclusionsTwin and general populations have similar patterns of lung function change over middle childhood and adolescence. Similar equations may be used to estimate percent predicted values. Finally, a single prediction equation cannot completely describe patterns of lung function from childhood through adolescence due to puberty related changes. Pediatr Pulmonol. 2007; 42:631–639. © 2007 Wiley‐Liss, Inc.