Dopaminergic Modulation of Resting-State Functional Connectivity in De Novo Patients With Parkinson's Disease
Dopaminergic Modulation of Resting-State Functional Connectivity in De Novo Patients With Parkinson's Disease
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DOI：
10.1002/hbm.22561
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发表时间：
2014-11-01
影响因子：
4.8
通讯作者：
Lee, Phil Hyu
中科院分区：
文献类型：
--
作者：
Baik, KyoungWon;Cha, Jungho;Lee, Phil Hyu
帕金森病（PD）的特征是黑质多巴胺神经元的退行性改变，导致纹状体多巴胺能神经支配的失。静息状态网络研究表明，多巴胺调制不同的网络连接模式，在线性和非线性的方式，但多巴胺依赖的功能连接的定量分析继发于PD病理信息较少。在本研究中，我们进行了相关性分析纹状体多巴胺水平的定量评估FP-CIT正电子发射断层扫描成像和静息态功能连接在23个药物初治的原发性PD患者阐明多巴胺依赖的功能网络。主要的发现是多巴胺依赖的正功能连接的模式根据纹状体种子的位置而变化。多巴胺依赖的功能连接与尾状核主要覆盖中央周围皮质区，而多巴胺依赖的结构功能连接与后壳核主要涉及小脑区。额叶背外侧区重叠为多巴胺依赖的皮质区，与前壳核和后壳核呈正相关。另一方面，皮质区，从后扣带回的功能连接呈负相关，多巴胺能状态在后壳核位于左前额叶区和顶叶区。此外，前壳核和近中额区之间的功能连接与纹状体多巴胺水平呈负相关。目前的研究表明，多巴胺依赖的功能网络连接继发于PD病理主要表现出一致的模式，虽然有一些变化。这些模式可能反映了多巴胺能药物对帕金森病相关运动和认知表现的不同影响。《脑地图》35：5431-5441，2014年。(c)2014 Wiley Periodicals，Inc.
Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naive de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance. Hum Brain Mapp 35:5431-5441, 2014. (c) 2014 Wiley Periodicals, Inc.