ENHANCED SERUM LEVELS OF THIOBARBITURIC ACID-REACTIVE SUBSTANCES IN DIABETES-MELLITUS
ENHANCED SERUM LEVELS OF THIOBARBITURIC ACID-REACTIVE SUBSTANCES IN DIABETES-MELLITUS
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DOI：
10.1016/s0002-9343(99)80347-7
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发表时间：
1995-05-01
影响因子：
5.9
通讯作者：
MUELLER, MM
中科院分区：
文献类型：
--
作者：
GRIESMACHER, A;KINDHAUSER, M;MUELLER, MM
目得：为了研究I型和II型糖尿病患者血清中以硫代巴比妥酸反应物质（TEARS）测量的脂质过氧化物水平是否不同，血清水平是否与糖尿病晚期后遗症相关，以及血清游离维生素E水平是否与脂质过氧化副产物水平相关。在158例患者中测定了血脂、糖化血红蛋白A（1c）（HbA（1c））、过氧化脂质（以泪液计）和游离维生素E之间的关系。77例I型糖尿病患者中有15例和81例II型糖尿病患者中有39例有明显的外周血管病变或冠状动脉病变，或两者兼有。
PURPOSE: TO investigate whether serum levels of lipid peroxides measured as thiobarbituric-acid-reactive substances (TEARS) differ in type I and type II diabetic patients, whether serum levels correlate with late sequelae of diabetes, and whether serum levels of free vitamin E correlate with levels of lipid peroxidation by-products.PATIENTS AND METHODS: The relationship among lipids, glycosylated hemoglobin A(1c) (HbA(1c)), lipid peroxides measured as TEARS, and free vitamin E was determined in 158 patients. Fifteen of the 77 patients with type I diabetes and 39 of the 81 patients with type II diabetes had clinically apparent peripheral vascular disease or coronary artery disease, or both.RESULTS: Compared with control subjects, serum levels of TEARS were found to be significantly elevated (P