Using MALDI-TOF mass spectrometry to characterize interfacial reactions on self-assembled monolayers
Using MALDI-TOF mass spectrometry to characterize interfacial reactions on self-assembled monolayers
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DOI：
10.1021/la034071y
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发表时间：
2003-06-10
期刊：
影响因子：
3.9
通讯作者：
Mrksich, M
中科院分区：
文献类型：
--
作者：
Su, J;Mrksich, M
本文表明，基质辅助激光解吸/电离和飞行时间质谱（MALDI-TOF MS）是非常适合表征自组装单分子膜（SAMs）的烷硫醇金，特别是，用于分析化学反应的单分子膜。三个示例为此目的建立了MALDI-TOF的通用性。第一个实施例表征了环戊二烯与单层的马来酰亚胺基团的狄尔斯-阿尔德反应。第二个实施例表征了谷氨酰胺叔丁基酯固定到羧酸封端的单层上并随后除去叔丁基。第三实施例表征了单层中的烷硫醇盐与接触溶液中的烷硫醇的交换。MALDI-TOF MS的商业仪器的可用性和直接使用这种技术来表征SAMs将使其成为化学和材料科学中制备和应用模型基底的程序的重要分析技术。
This paper demonstrates that matrix-assisted laser desorption/ionization and time-of-flight mass spectrometry (MALDI-TOF MS) is very well suited for characterizing self-assembled monolayers (SAMs) of alkanethiolates on gold and, in particular, for analyzing chemical reactions on monolayers. Three examples establish the generality of MALDI-TOF for this purpose. The first example characterizes the Diels-Alder reaction of a cyclopentadiene to maleimide groups of a monolayer. The second example characterizes the immobilization of glutamine tert-butyl ester to a carboxylic acid terminated monolayer and subsequent removal of the tert-butyl group. The third example characterizes the exchange of alkanethiolates in a monolayer with alkanethiols in a contacting solution. The availability of commercial instruments for MALDI-TOF MS and the straightforward use of this technique for characterizing SAMs will make this an important analytical technique for programs that prepare and apply model substrates in chemistry and materials science.