Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood
Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood
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DOI：
10.4269/ajtmh.1997.57.426
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发表时间：
1997-10-01
影响因子：
3.3
通讯作者：
Vanderberg, JP
中科院分区：
文献类型：
--
作者：
Sidjanski, S;Vanderberg, JP
本文研究了斯氏按蚊将约氏疟原虫子孢子带入BALB/C小鼠皮肤的情况。当受感染的蚊子以耳朵的一部分为食时，这些阳性对照小鼠中有81%发生寄生虫血症。当喂食后立即或5分钟切除喂食部位时，这些实验小鼠中发生寄生虫血症的百分比非常显著，当蚊子叮咬组织的去除延迟延长至15分钟时，该组与阳性对照小鼠之间没有发现显著差异。这些发现表明，蚊子注射的子孢子倾向于在蚊子叮咬后在叮咬部位保留至少5分钟。到大约15分钟时，第一波迁移的子孢子已经离开叮咬部位并进入体循环。这些研究结果可能涉及宿主通过抗子孢子抗体或对蚊子叮咬的皮肤超敏反应阻碍子孢子在皮肤中的迁移。
Studies were done on delivery of Plasmodium yoelii sporozoites by Anopheles stephensi into the skin of BALB/C mice. When infected mosquitoes fed on a portion of the ear, 81% of these positive control mice developed parasitemia. When the fed-upon site was excised immediately or 5 min postfeeding, a highly significant, smaller percentage of these experimental mice developed parasitemia, When the delay in removal of mosquito-bitten tissue was extended to 15 min, no significant difference was found between this group and positive control mice. These findings show that mosquito-injected sporozoites tend to remain at the bite site for at least 5 min after the mosquito bite. By approximately 15 min, the first wave of migrating sporozoites has left the bite site and moved into the general circulation. These findings have implications concerning possible host obstruction of sporozoite migration in skin by either anti-sporozoite antibodies or by a cutaneous hypersensitivity reaction to mosquito bite.