Tumor Microenvironment-Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy.
Tumor Microenvironment-Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy.
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DOI：
10.1002/adma.201605928
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
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作者：
Chu C;Lin H;Liu H;Wang X;Wang J;Zhang P;Gao H;Huang C;Zeng Y;Tan Y;Liu G;Chen X
光敏剂在癌症光疗中的功效通常受到光漂白、低肿瘤选择性和肿瘤缺氧的限制。将光敏剂组装到纳米结构中可以提高光敏剂的光动力治疗功效和安全性。本文通过采用超分子组装，证明了光敏剂（中卟啉钠，DVDMS）的Mn 2+辅助组装的增强的治疗诊断能力。进一步开发肿瘤环境触发的共组装策略以形成用于癌症光疗的Mn/DVDMS纳米治疗剂（nanoDVD）。MnO 2纳米片作为一种高效的DVDMS载体和原位氧和nanoDVD发生器。在MCF-7细胞和异种移植肿瘤中，MnO 2/DVDMS被谷胱甘肽（GSH）和H2 O2还原并重新组装成nanoDVD，可以通过激活的磁共振/荧光/光声信号进行监测。有趣的是，GSH的减少、O2的产生和nanoDVD的形成被证明与光疗协同作用，以提高体外和体内的抗肿瘤功效，为癌症治疗诊断学提供了新的途径。
The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn2+-assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment-triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy. MnO2 nanosheets serve as a highly effective DVDMS carrier and in situ oxygen and nanoDVD generator. In MCF-7 cells and xenograft tumors, MnO2/DVDMS is reduced by glutathione (GSH) and H2O2 and reassembled into nanoDVD, which can be monitored by activated magnetic resonance/fluorescence/photoacoustic signals. Intriguingly, the decrease of GSH, the production of O2, and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor efficacy in vitro and in vivo, offering a new avenue for cancer theranostics.