Essential role of TNF-alpha in development of spleen fibroblastic reticular cells
Essential role of TNF-alpha in development of spleen fibroblastic reticular cells
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TNF-α 在脾成纤维细胞网状细胞发育中的重要作用。
DOI：
10.1016/j.cellimm.2015.01.006
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发表时间：
2015-02-01
影响因子：
4.3
通讯作者：
Zhu, Bo
中科院分区：
文献类型：
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作者：
Zhao, Lintao;Chen, Junying;Zhu, Bo
TNF-α在次级淋巴组织的发育中起着重要作用。早期研究表明成纤维细胞网状细胞表达TNF-α受体，提示TNF-α可能影响FRC的发育。为了测试这一点，我们分析了野生型或 TNF-α 敲除小鼠中 FRC 的发育和功能。我们发现 TNFα 敲除小鼠的脾脏中 GP38 表达下调。主要由 GP38(+) FRC 分泌的趋化因子也下调。此外，我们发现 TNF-α 的缺失降低了 T 细胞定向至脾脏的归巢能力。然而，TNF-α 的缺失并不影响淋巴结 FRC 的发育。这些数据表明 TNF-α 在脾脏 FRC 的发育中起着重要作用。 TNF-α的缺失可能导致脾脏FRC异常，从而削弱T细胞定位于脾脏T细胞区的归巢能力。 (C) 2015 Elsevier Inc. 保留所有权利。
TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function of FRCs in wild-type or TNF-alpha knockout mice. We found that GP38 expression was down-regulated in the spleen of TNFalpha knockout mice. Chemokines, mainly secreted by GP38(+) FRCs, were also down-regulated. Additionally, we found that absence of TNF-alpha decreased the homing ability to direct T cells to the spleen. However, absence of TNF-alpha did not affect the development of lymph nodes FRCs. These data reveal that TNF-alpha plays an important role in the development of spleen FRCs. Absence of TNF-alpha could cause abnormality of spleen FRCs, thereby weakening the homing ability of T cells to localize to the spleen T cell zone. (C) 2015 Elsevier Inc. All rights reserved.