The distribution of collagen in human articular cartilage with some of its physiological implications.
The distribution of collagen in human articular cartilage with some of its physiological implications.
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DOI：
10.1302/0301-620x.52b3.554
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发表时间：
1970-08
期刊：
影响因子：
--
通讯作者：
H. Muir;P. Bullough;A. Maroudas
中科院分区：
文献类型：
--
作者：
H. Muir;P. Bullough;A. Maroudas
1.对26~60岁健康成人股骨髁骨关节软骨连续切片进行了化学、电子显微镜和通透性检查。2.化学分析和电子显微镜显示，最浅层的胶原含量最高，随着距离关节表面的距离，胶原含量急剧下降。另一方面，表层糖胺多糖含量很低，但随深度的增加而增加。在所有被测试的样本中都发现了这种差异，但胶原蛋白和糖胺聚糖的绝对水平差别很大。化学成分与年龄无相关性。3.浅层胶原纤维直径明显小于深层。4.水力通透性更多地依赖于糖胺聚糖，而不是胶原含量，尽管它与这两个因素成反比。5.实验结果表明，软骨的物理性质与其化学成分密切相关。
1. Serial slices of articular cartilage obtained at necropsy from apparently normal femoral condyles of individuals between the ages of twenty-six and sixty were examined chemically, by electron microscopy and for permeability. 2. The most superficial layer was shown by chemical analysis and electron microscopy to have the highest collagen content, which fell sharply with distance from the articular surface. On the other hand the glycosaminoglycan content was very low in the superficial layers but increased with depth. This variation was found in all specimens tested but the absolute levels of collagen and of glycosaminoglycans were widely different. There was no correlation of chemical composition with age. 3. Collagen fibrils in the superficial layer were of much smaller diameter than in the deeper zones. 4. Hydraulic permeability was shown to depend more on glycosaminoglycan than on collagen content, although it varied inversely with both these factors. 5. The results obtained demonstrate clearly the close relation between the physical properties of cartilage and its chemical composition.