Dynamics of gametes and embryos in the oviduct: what can in vivo imaging reveal?
Dynamics of gametes and embryos in the oviduct: what can in vivo imaging reveal?
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DOI：
10.1530/rep-22-0250
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发表时间：
2023-02-01
期刊：
影响因子：
3.8
通讯作者：
Larina, Irina, V
中科院分区：
文献类型：
--
作者：
Wang, Shang;Larina, Irina, V
了解配子和胚胎在输卵管内的生理动力学对管理生殖障碍和改进辅助生殖技术具有重要意义。在小鼠体内输卵管成像的最新进展揭示了配子和胚胎在其原生状态下的迷人动态。这些新的成像方法和观察带来了令人兴奋的势头，揭示了原本隐藏的受精和怀孕过程。对于机制研究，在遗传小鼠模型中的体内成像能够在生殖过程中实现基因功能的动态表型。在此，我们回顾了这些成像方法，讨论了体内成像的最新发现，并对新兴方向进行了评论，旨在促进新的生殖动力学的体内研究。输卵管内配子和胚胎的体内成像为研究导致受精和怀孕的自然过程提供了新的途径。本文综述了近年来在体内成像方法和见解的进展，有助于了解输卵管功能。
Understanding the physiological dynamics of gametes and embryos in the fallopian tube (oviduct) has significant implications for managing reproductive disorders and improving assisted reproductive technologies. Recent advancements in imaging of the mouse oviduct in vivo uncovered fascinating dynamics of gametes and embryos in their native states. These new imaging approaches and observations are bringing exciting momentum to uncover the otherwise-hidden processes orchestrating fertilization and pregnancy. For mechanistic investigations, in vivo imaging in genetic mouse models enables dynamic phenotyping of gene functions in the reproductive process. Here, we review these imaging methods, discuss insights recently revealed by in vivo imaging, and comment on emerging directions, aiming to stimulate new in vivo studies of reproductive dynamics. In vivo imaging of gametes and embryos in the oviduct enables new studies of the native process leading to fertilization and pregnancy. This review article discusses recent advancements in the in vivo imaging methods and insights which contribute to understanding the oviductal function.
影响因子：
17.3
作者：
Kitamura, Takanori;Pollard, Jeffrey W.;Vendrell, Marc
通讯作者：
Vendrell, Marc