Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells
Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells
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DOI：
10.3748/wjg.v16.i5.618
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发表时间：
2010-02-07
影响因子：
4.3
通讯作者：
Wan, Mo-Bin
中科院分区：
文献类型：
--
作者：
Liang, Xue-Song;Zhou, Ying;Wan, Mo-Bin
目的：为探讨程序性死亡1型（PD-1）表达是否以及如何影响8型肝炎病毒（HBV）感染的自然病程。流式细胞术检测总T细胞中PD-1的表达。结果：在慢性HBV感染的自然病程中，T细胞PD-1表达呈动态变化，在免疫耐受期无明显增加，在病毒携带者失活期恢复正常。阻断PD-1/PD-L1通路不会影响慢性HBV感染的免疫耐受和非活动性病毒携带阶段的T细胞应答。然而，它可以显着恢复慢性HBV感染的免疫清除阶段的T细胞反应。结论：PD-1/PD-L1通路在慢性HBV感染的自然病程中对T细胞应答起着不同的作用。(C)2010年百世登。All rights reserved.
AIM: To investigate if and how programmed death type-1 (PD-1) expression affects the natural course of hepatitis 8 virus (HBV) infection.METHODS: Sixty-four patients in different natural stages of chronic HBV infection were enrolled in this study. PD-1 expression in total T cells was detected by flow cytometry. Levels of total CD8+ T cell responses and proliferation in relation to PD-1 expression levels were analyzed with intracellular staining and PD-1/PD-L1 blockage.RESULTS: The PD-1 expression in T cells was dynamically changed during the natural course of chronic HBV infection, did not significantly increase in the immune tolerance phase, and returned to normal in the inactive virus carrier stage. Blockage of the PD-1/PD-L1 pathway could not affect the T-cell response in the immune tolerance and inactive virus carrier stages of chronic HBV infection. However, it could significantly restore the T-cell response in the immune clearance stage of chronic HBV infection. Furthermore, the PD-1 expression level in T cells was associated with the alanine aminotransferase level during the immune clearance stage of chronic HBV infection.CONCLUSION: The PD-1/PD-L1 pathway plays a different role in T-cell response during the natural course of chronic HBV infection. (C) 2010 Baishideng. All rights reserved.