Macrophage Biology in Cardiovascular Diseases.
Macrophage Biology in Cardiovascular Diseases.
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心血管疾病中的巨噬细胞生物学。
DOI：
10.1161/atvbaha.120.313584
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Liu B
中科院分区：
文献类型：
--
作者：
Khoury MK;Yang H;Liu B
巨噬细胞在动脉粥样硬化、主动脉瘤等多种心血管疾病的发病机制中起着关键作用。它们在血管壁内的积累导致持续的局部炎症反应，其特征在于分泌趋化因子、细胞因子和基质蛋白降解酶。在这里，我们总结了最近的研究结果，巨噬细胞的贡献，心血管疾病发表在ATVB。在这个问题上，我们专注于血管壁内巨噬细胞的起源，生存/死亡和表型转换。
Macrophages have key functional role in the pathogenesis are various cardiovascular diseases, such as atherosclerosis and aortic aneurysm. Their accumulation within the vessel wall leads to sustained local inflammatory responses characterized by secretion of chemokines, cytokines, and matrix protein degrading enzymes. Here, we summarize recent findings on macrophage contribution to cardiovascular disease published in ATVB. In this issue, we focus on the origin, survival/death, and phenotypic switching of macrophages within vessel walls.