Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens.
Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens.
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DOI：
10.1007/s00213-014-3734-8
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Miczek, Klaus A.
中科院分区：
文献类型：
--
作者：
Han, Xiao;Albrechet-Souza, Lucas;Doyle, Michelle R.;Shimamoto, Akiko;DeBold, Joseph F.;Miczek, Klaus A.
社交失败压力导致大鼠可卡因服用和长期神经适应的升级。社交失败压力的强度和时间如何决定这些影响，特别是在小鼠中，还没有得到很好的表征。本研究采用体内微透析技术研究了轻度与中度社会应激强度和持续时间对静脉注射可卡因自我给药以及对多巴胺（DA）释放的影响。成年雄性CFW小鼠经历了10天的社交失败压力，无论是轻度的（约15次攻击咬伤），1.8分钟）或中度（约30次攻击性叮咬）。3.6 min），并与每天处理的对照组进行比较。随后，评估了社交应激小鼠的（1）静脉内可卡因自我给药，在有限的访问条件下使用几个单位剂量（0，0.3，0.6，1.0 mg/kg/输注），或（2）神经致敏，如通过体内微透析NAcSh中的DA对急性d-苯丙胺攻击的反应所确定的。社会挫折压力导致可卡因自我管理在轻度和中度的社会压力组升级。此外，社交失败压力导致增加DA释放后，d-安非他明的挑战。这些数据表明，轻度和中度的社会压力的小鼠表现出增加可卡因服用相比，控制，这种增加与升级的多巴胺能反应的NAcSh。
Social defeat stress results in escalation of cocaine taking and long-term neural adaptations in rats. How the intensity and timing of social defeat stress determine these effects, particularly in mice, have not been well characterized. This study investigated the effects of mild vs. moderate intensities and durations of social stress on intravenous cocaine self-administration as well as on dopamine (DA) release in nucleus accumbens shell (NAcSh) by using in vivo microdialysis. Adult male CFW mice experienced 10 days of social defeat stress, either mild (15 attack bites in ca. 1.8 min) or moderate (30 attack bites in ca. 3.6 min), and compared to controls that were handled daily. Subsequently, the socially stressed mice were assessed for either (1) intravenous cocaine self-administration, using several unit doses (0, 0.3, 0.6, 1.0 mg/kg/infusion) under limited access conditions, or (2) neural sensitization, as determined by in vivo microdialysis of DA in the NAcSh in response to acute d-amphetamine challenge. Social defeat stress resulted in escalated cocaine self-administration in both mild and moderate socially stressed groups. In addition, social defeat stress led to increased DA release after d-amphetamine challenge. These data suggest that both mild and moderate socially stressed mice exhibit increased cocaine taking compared to controls, and this increase is associated with escalated dopaminergic responses in the NAcSh.
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DOI：
10.1523/jneurosci.0637-11.2011
发表时间：
2011-07-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Miczek KA;Nikulina EM;Shimamoto A;Covington HE 3rd
通讯作者：
Covington HE 3rd
早期社会隔离破坏成年大鼠内侧前额皮质和伏核的潜在抑制并增加多巴胺 D2 受体表达
影响因子：
2.9
作者：
Han, Xiao;Li, Nanxin;Wang, Weiwen
通讯作者：
Wang, Weiwen
影响因子：
3.4
作者：
Caine, SB;Negus, SS;Mello, NK
通讯作者：
Mello, NK
DOI：
10.1073/pnas.92.26.12304
发表时间：
1995-12-19
影响因子：
11.1
作者：
Pontieri, FE;Tanda, G;DiChiara, G
通讯作者：
DiChiara, G
影响因子：
3.4
作者：
Miczek, KA;Mutschler, NH
通讯作者：
Mutschler, NH