Pre- or post-treatment with the mitochondrial uncoupler 2,4-dinitrophenol attenuates striatal quinolinate lesions.
Pre- or post-treatment with the mitochondrial uncoupler 2,4-dinitrophenol attenuates striatal quinolinate lesions.
复制标题
使用线粒体解偶联剂 2,4-二硝基苯酚进行治疗前或治疗后可减轻纹状体喹啉盐损伤。
DOI：
10.1016/s0006-8993(02)04225-7
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发表时间：
2003
期刊：
影响因子：
2.9
通讯作者：
Young,KristieL
中科院分区：
文献类型：
--
作者：
Maragos,WilliamF;Rockich,KevinT;Dean,JesseJ;Young,KristieL
We have examined the neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in animals receiving striatal injections of the neurotoxin quinolinic acid. Animals administered DNP either 1 h before or 3 h following QA infusion developed lesions that were 25% smaller than control animals. Animals treated with the DNP analogue 2,4,6-trinitrophenol, which does not possess uncoupling activity in intact mitochondria, showed no neuroprotection. These results indicate that DNP, and other compounds that diminish the mitochondrial membrane potential, might provide a novel approach to the treatment of acute neurological injury.
