Orbitofrontal cortex and human drug abuse: Functional imaging
Orbitofrontal cortex and human drug abuse: Functional imaging
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DOI：
10.1093/cercor/10.3.334
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发表时间：
2000-03-01
期刊：
影响因子：
3.7
通讯作者：
Weinstein, A
中科院分区：
文献类型：
--
作者：
London, ED;Ernst, M;Weinstein, A
眶额皮质（OFC）在人类行为中起着核心作用。解剖学上与所有感觉方式的关联区域，边缘结构相连。在调节执行功能的前额叶皮层区域和皮层下核中，该大脑区域可以用于整合刺激对象的物理和情感属性，并基于对潜在奖励的估计来建立激励值。在某种程度上，成瘾性障碍反映了评估潜在回报与自我给药伤害的能力失调。可以预期，物质滥用障碍可能反映了眶额皮层功能障碍。随着脑成像技术在人类药物滥用研究中的应用，已有证据表明，眶额皮层及其连接的活动在药物滥用的适应不良行为的几个组成部分中发挥作用，包括期望，渴望和决策障碍。
The orbitofrontal cortex (OFC) plays a central role in human behavior. Anatomically connected with association areas of all sensory modalities, limbic structures. prefrontal cortical regions that mediate executive function and subcortical nuclei, this brain region can serve to integrate the physical and emotional attributes of a stimulus-object and establish a motivational value based on estimation of potential reward. To the extent that addictive disorders reflect a dysregulation of the ability to evaluate potential reward against harm from drug self-administration. it would be anticipated that substance abuse disorder might reflect dysfunction of the OFC. With the application of brain imaging techniques to the study of human substance abuse, evidence has been obtained that activity in the OFC and its connections plays a role in several components of the maladaptive behavior of substance abuse, including expectancy, craving and impaired decision making.