Combined pharmacological and electrophysiological dissociation of familiarity and recollection
Combined pharmacological and electrophysiological dissociation of familiarity and recollection
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DOI：
10.1523/jneurosci.5370-05.2006
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发表时间：
2006-02-15
影响因子：
5.3
通讯作者：
Hirshman, E
中科院分区：
文献类型：
--
作者：
Curran, T;DeBuse, C;Hirshman, E
识别记忆的双过程理论假设了不同的熟悉过程和回忆过程，但多过程的必要性是有争议的。先前的研究表明，头皮记录的事件相关脑电位（ERPs）可能会索引单独的熟悉过程和回忆过程的活动。其他研究表明，遗忘药物咪达唑仑对记忆的损害比熟悉程度更大。在这里，我们使用趋同的药理学和电生理学方法来操纵和监测人类大脑活动，并为单独的过程提供证据。咪达唑仑选择性地影响了假设的erp相关的回忆，而不是假设的erp相关的熟悉。在对照条件下（生理盐水），被试的准确性与回忆相关的ERP成分相关，而与熟悉相关的ERP成分无关，这表明回忆在驱动记忆方面占主导地位。在咪达唑仑组中观察到相反的模式，这表明当回忆失败时，受试者可能会利用熟悉度来弥补。因此，与认为熟悉代表默认过程的观点相反，这些结果表明，回忆在其损害揭示了熟悉的影响之前一直占主导地位。
Dual-process theories of recognition memory hypothesize separate underlying familiarity and recollection processes, but the necessity of multiple processes is debated. Previous research has suggested that scalp-recorded event-related brain potentials (ERPs) may index the activity of separate familiarity and recollection processes. Other research indicates that the amnestic drug midazolam impairs recollection more than familiarity. Here, we used a convergent pharmacological and electrophysiological approach to manipulate and monitor human brain activity and provide evidence for separate processes. Midazolam selectively influenced the putative ERP-correlate of recollection but not the putative ERP-correlate of familiarity. Under control conditions (saline), subjects' accuracy correlated with the recollection-related but not the familiarity-related ERP component, suggesting that recollection was dominant in driving memory. The opposite pattern was observed under midazolam administration, suggesting that when recollection fails, subjects may leverage familiarity to compensate. Thus, in contrast to perspectives holding that familiarity represents the default process, these results suggest that recollection was dominant until its impairment unveiled the influence of familiarity.