Expansion of γδ T-cells in Behcet's disease:: Role of disease activity and microbial flora in oral ulcers
Expansion of γδ T-cells in Behcet's disease:: Role of disease activity and microbial flora in oral ulcers
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DOI：
10.1067/mlc.2003.1
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发表时间：
2003-01-01
期刊：
影响因子：
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通讯作者：
Livneh, A
中科院分区：
文献类型：
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作者：
Bank, I;Duvdevani, M;Livneh, A
γδ T 细胞通过识别细菌来源的抗原和自体抗原参与对感染的免疫反应和自身免疫。本研究的目的是评估 γδ T 细胞在白塞氏病 (BD) 中的参与情况。通过流式细胞术评估了患有明确 BD 的以色列患者 (n = 23)、正常对照 (n = 16) 和家族性地中海热患者 (FMF; n = 20) 的外周血单核细胞 (PBMC) 中的 γδ T 细胞。比较了患者和对照 γδ T 细胞对由活动性 BD 患者口腔溃疡培养的微生物所调节的培养基的反应。 PBMCs中CD3(+)和CD8(+)细胞的比例在各组之间没有显着差异。相比之下，在 BID 中，γδ-T 细胞占 PBMC 的 7.01% +/- 4.42%，而在 FMF 中占 3.56% +/- 3.45% (P < .005)，在正常个体中占 3.7% +/- 3.15% (P
gammadelta T-cells participate in the immune response to infections and in autoimmunity by recognizing bacteria-derived and autologous antigens. The goal of this study was to evaluate the involvement of gammadelta T-cells in Behcet's disease (BD). gammadelta T-cells in the peripheral-blood mononuclear cells (PBMCs) of Israeli patients with definite BD (n = 23) normal controls (n = 16), and patients with familial Mediterrranean fever (FMF; n = 20) were evaluated by means of flow cytometry. The responses of patient and control gammadelta T-cells to medium conditioned by microorganisms cultured from an oral ulcer of a patient with active BD were compared. The proportions of CD3(+) and CD8(+) cells in the PBMCs were not significantly different between groups. In contrast, gammadelta-T-cells accounted for 7.01% +/- 4.42% of the PBMCs in BID compared with 3.56% +/- 3.45% in FMF (P < .005) and 3.7% +/- 3.15% in normal individuals (P