The Janus protein tyrosine kinases in hematopoietic cytokine signaling.
The Janus protein tyrosine kinases in hematopoietic cytokine signaling.
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DOI：
10.1006/smim.1995.0029
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发表时间：
1995-08-01
影响因子：
7.8
通讯作者：
Ihle, J N
中科院分区：
文献类型：
--
作者：
Ihle, J N
细胞因子通过与细胞因子受体超家族成员的相互作用来调节细胞功能。这些受体通过与Janus蛋白酪氨酸激酶（Jaks）结合，将配体结合与酪氨酸磷酸化诱导偶联。受体二聚化诱导Jak同源或异源缔合、自磷酸化和Jak催化活性的活化。假设活化的Jak使受体以及参与细胞信号传导的许多蛋白质磷酸化，所述蛋白质包括SHC、PI 3-激酶的p85亚基、Vav和转录因子的信号转导和转录激活因子（Stats）家族的成员。受体磷酸化还允许造血细胞磷酸酶与受体复合物结合，导致其下调。受体突变体允许识别每个功能所需的特定结构域及其与生物反应的相关性。
Cytokines regulate cellular functions through their interaction with members of the cytokine receptor superfamily. These receptors couple ligand binding to induction of tyrosine phosphorylation through their association with the Janus protein tyrosine kinases (Jaks). Receptor dimerization induces Jak homo- or hetero-associations, autophosphorylation and activation of Jak catalytic activity. The activated Jaks are hypothesized to phosphorylate the receptors as well as a number of proteins involved in cellular signaling including SHC, the p85 subunit of PI 3-kinase, Vav and members of the Signal Transducers and Activators of Transcription (Stats) family of transcription factors. Receptor phosphorylation also allows association of hematopoietic cell phosphatase with the receptor complex, resulting in its down-regulation. Receptor mutants have allowed the identification of specific domains that are required for each function and their correlation with biological responses.