Biocompatible fluorescent polymers from PEGylation of an aggregation-induced emission dye
Biocompatible fluorescent polymers from PEGylation of an aggregation-induced emission dye
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DOI：
10.1016/j.dyepig.2016.12.070
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发表时间：
2017-04
影响因子：
4.5
通讯作者：
Chunping Ma;Xie Gaoyi;Xiqi Zhang;Liutao Yang;Li Yang-;Hongliang Liu;K. Wang;Yen Wei
中科院分区：
文献类型：
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作者：
Chunping Ma;Xie Gaoyi;Xiqi Zhang;Liutao Yang;Li Yang-;Hongliang Liu;K. Wang;Yen Wei
以聚乙二醇单甲醚甲酯为原料，通过可逆加成断裂链转移聚合，与一种含乙烯基团的新型聚集诱导发射(AIE)单体进行聚合反应，制备了新型AIE聚合物(NS1和NS2)。用凝胶渗透色谱、核磁共振氢谱、红外光谱、X-射线光电子能谱对NS1和NS2共聚物进行了表征，证明了它们的合成是成功的。这种两亲性共聚物在水中可以自组装成具有良好分散性的球形荧光聚合物纳米颗粒。制备的NS2FP具有50~150 nm的绿色荧光，水溶液中的荧光量子产率为31%，临界胶束浓度为0.030 mg/m L−1。NS2FP的尺寸范围为200~300 m g，荧光强度为38%，临界胶束浓度为0.037 mg/m L−1。由于聚乙二醇改性具有良好的生物相容性、低cmc下具有良好的粒子稳定性以及具有高光稳定性的AIE荧光聚合物，本工作构建的FP网络显示出明显的优势。这一策略将启发新的方法来制备用于生物医学应用的新型生物相容AIE荧光聚合物。
Novel aggregation-induced emission (AIE) polymers (NS1andNS2) were prepared through reversible addition fragmentation chain transfer polymerization of poly(ethylene glycol) monomethyl ether methacylate and a new AIE monomer with a vinyl group. TheNS1andNS2copolymers were characterized by gel permeation chromatography,1H NMR spectroscopy, FT-IR spectroscopy, X-ray photoelectron spectroscopy, which proved their successful syntheses. Such amphiphilic copolymers could self-assemble into fluorescent polymeric nanoparticles (FPNs) in water with good dispersibility, which were spherical in shape. The prepared FPNs ofNS1had a size range of 50–150 nm, strong green fluorescence in aqueous solution with fluorescence quantum yield of 31%, and low critical micelle concentration (CMC) of 0.030 mg mL−1. TheNS2FPNs exhibited size range of 200–300 nm, intense green fluorescence with quantum yield of 38%, and CMC of 0.037 mg mL−1. These FPNs were demonstrated highly biocompatible for cell imaging. By virtue of excellent biocompatibilityviaPEG modification, good particle stability with low CMC, and AIE fluorescent polymers with high photostability, the FPNs constructed in this work showed obvious advantages. This strategy should inspire new approaches to prepare novel biocompatible AIE fluorescent polymers for biomedical application.