Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus
Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus
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DOI：
10.1212/wnl.55.11.1636
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发表时间：
2000-12-12
期刊：
影响因子：
9.9
通讯作者：
Miller, MI
中科院分区：
文献类型：
--
作者：
Csernansky, JG;Wang, L;Miller, MI
目的：为了确定使用高维脑映射（HDBM）评估老年人受试者海马结构的可行性，并比较阿尔茨海默型早期痴呆（DAT）受试者与健康老年人和年轻对照受试者海马体积和形状的测量结果，背景：HDBM通过构造模板来表示大脑的典型结构，并通过应用于模板的概率变换来解决其可变性。在整个大脑中局部应用变换（即，方法：对18例轻度DAT患者、18例健康老年人和15例健康年轻人进行MR扫描。HDBM用于获得左右海马体积和特征向量的估计，这些特征向量代表受试者组之间海马形状差异的主要维度。结果如下：在DAT受试者中观察到的海马体积损失和形状变形将其与老年和年轻对照受试者区分开来。DAT受试者的海马畸形模式在很大程度上是对称的，并建议损害CA1海马子区。在健康的老年受试者中也观察到海马形状变化，这将他们与健康的年轻受试者区分开来。这些形状变化发生的模式与DAT中观察到的模式不同，并且与大量体积损失无关。结论：HDBM评估海马体积和形状可能有助于区分早期DAT和健康老龄化。
Objective: To determine the feasibility of using high-dimensional brain mapping (HDBM) to assess the structure of the hippocampus in older human subjects, and to compare measurements of hippocampal volume and shape in subjects with early dementia of the Alzheimer type (DAT) and in healthy elderly and younger control subjects, Background: HDBM represents the typical structures of the brain via the construction of templates and addresses their variability by probabilistic transformations applied to the templates. Local application of the transformations throughout the brain (i.e., high dimensionality) makes HDBM especially valuable for defining subtle deformities in brain structures such as the hippocampus, Methods: MR scans were obtained in 18 subjects with very mild DAT, 18 healthy elderly subjects, and 15 healthy younger subjects. HDBM was used to obtain estimates of left and right hippocampal volume and eigenvectors that represented the principal dimensions of hippocampal shape differences among the subject groups. Results: Hippocampal volume loss and shape deformities observed in subjects with DAT distinguished them from both elderly and younger control subjects. The pattern of hippocampal deformities in subjects with DAT was largely symmetric and suggested damage to the CA1 hippocampal subfield. Hippocampal shape changes were also observed in healthy elderly subjects, which distinguished them from healthy younger subjects. These shape changes occurred in a pattern distinct from the pattern seen in DAT and were not associated with substantial volume loss. Conclusions: Assessments of hippocampal volume and shape derived from HDBM may be useful in distinguishing early DAT from healthy aging.