The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
复制标题
在帕金森氏病的急性和进步模型中，肠道神经病与肠道表型的关联。
DOI：
10.1038/s41598-021-86917-5
复制
发表时间：
2021-04-12
影响因子：
4.6
通讯作者：
Diwakarla S
中科院分区：
文献类型：
--
作者：
McQuade RM;Singleton LM;Wu H;Lee S;Constable R;Di Natale M;Ringuet MT;Berger JP;Kauhausen J;Parish CL;Finkelstein DI;Furness JB;Diwakarla S
Parkinson’s disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervous system (ENS) of commonly used mouse models of PD that exhibit central neuropathy and a gut phenotype. Enteric neuropathy was assessed in five mouse models: peripheral injection of MPTP; intracerebral injection of 6-OHDA; oral rotenone; and mice transgenic for A53T variant human α-synuclein with and without rotenone. Changes in the ENS of the colon were quantified using pan-neuronal marker, Hu, and neuronal nitric oxide synthase (nNOS) and were correlated with GI function. MPTP had no effect on the number of Hu+ neurons but was associated with an increase in Hu+ nuclear translocation (P < 0.04). 6-OHDA lesioned mice had significantly fewer Hu+ neurons/ganglion (P < 0.02) and a reduced proportion of nNOS+ neurons in colon (P < 0.001). A53T mice had significantly fewer Hu+ neurons/area (P < 0.001) and exhibited larger soma size (P < 0.03). Treatment with rotenone reduced the number of Hu+ cells/mm2 in WT mice (P < 0.006) and increased the proportion of Hu+ translocated cells in both WT (P < 0.02) and A53T mice (P < 0.04). All PD models exhibited a degree of enteric neuropathy, the extent and type of damage to the ENS, however, was dependent on the model.
登录
查看更多内容
影响因子：
2.1
作者：
Feng, Xiao-Yan;Yan, Jing-Ting;Zhu, Jin-Xia
通讯作者：
Zhu, Jin-Xia
影响因子：
2.5
作者：
Blandini, F.;Balestra, B.;Tonini, M.
通讯作者：
Tonini, M.
影响因子：
2.7
作者：
Colucci, Mario;Cervio, Marila;Tonini, Marcello
通讯作者：
Tonini, Marcello
DOI：
10.1152/ajpgi.1998.274.6.g1024
发表时间：
1998-06-01
影响因子：
4.5
作者：
Filaretova, LP;Filaretov, AA;Makara, GB
通讯作者：
Makara, GB
DOI：
10.1007/978-1-4939-0897-4_3
发表时间：
2014-01-01
期刊：
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE
影响因子：
--
作者：
Furness, John B.;Callaghan, Brid P.;Cho, Hyun-Jung
通讯作者：
Cho, Hyun-Jung