Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives.
Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives.
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DOI：
10.3390/ijms22020913
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发表时间：
2021-01-18
影响因子：
5.6
通讯作者：
Donato G
中科院分区：
文献类型：
--
作者：
Di Vito A;Donato A;Presta I;Mancuso T;Brunetti FS;Mastroroberto P;Amorosi A;Malara N;Donato G
钙化性主动脉瓣疾病（CAVD）是发达国家和老龄化人群中最常见的心脏瓣膜病。它与中位年龄密切相关，影响65岁以上人口的13%。病理生理学分析表明CAVD是一种活动性和退行性疾病的结果，始于硬化和慢性炎症，然后是瓣叶钙化，最终可解释主动脉瓣狭窄。尽管CAVD最初被认为是一种被动事件，主要是由退行性衰老过程引起的，但许多证据表明钙化是由不同的主动过程引起的，涉及主动脉瓣驻留细胞（瓣膜内皮细胞，瓣膜间质细胞，间充质干细胞，先天免疫细胞）和循环细胞（循环间充质细胞，免疫细胞）。此外，细胞衍生的“基质囊泡”和细胞外基质（ECM）组分的作用也已被认识到。本文就CAVD发病过程中主动脉瓣细胞和分子的变化作一综述，重点探讨ECM在CAVD自然病程中的作用。
Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophysiological analysis indicates CAVD as a result of an active and degenerative disease, starting with sclerosis and chronic inflammation and then leaflet calcification, which ultimately can account for aortic stenosis. Although CAVD has been firstly recognized as a passive event mostly resulting from a degenerative aging process, much evidences suggests that calcification arises from different active processes, involving both aortic valve-resident cells (valve endothelial cells, valve interstitial cells, mesenchymal stem cells, innate immunity cells) and circulating cells (circulating mesenchymal cells, immunity cells). Moreover, a role for the cell-derived “matrix vesicles” and extracellular matrix (ECM) components has also been recognized. The aim of this work is to review the cellular and molecular alterations occurring in aortic valve during CAVD pathogenesis, focusing on the role of ECM in the natural course of the disease.
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DOI：
10.1073/pnas.1208916109
发表时间：
2012-08-28
影响因子：
11.1
作者：
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