Intellectual decline in children with moyamoya and sickle cell anaemia
Intellectual decline in children with moyamoya and sickle cell anaemia
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DOI：
10.1017/s001216220500174x
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发表时间：
2005-12-01
影响因子：
3.8
通讯作者：
Vargha-Khadem, F
中科院分区：
文献类型：
--
作者：
Hogan, AM;Kirkham, FJ;Vargha-Khadem, F
据报道，日本人群在患烟雾病后智力会下降，但在西方人群中这方面的证据较少，这种情况可能继发于中风和镰状细胞性贫血（SCA）。术前纵向智商数据来自15名中风后出现烟雾综合征（MMS）的儿童（7名男性，8名女性）（6名患有SCA， 9名不患有SCA）和19名对照（10名男性，9名女性；9名健康对照，10名患有SCA）。基线评估时（时间1）中位数。患者年龄为7岁6个月（3y - 7mo ~ 12y - 5mo）；对照组的中位年龄为6岁3个月（4岁至11岁6个月）。随访时（时间2），年龄11岁；患者和对照组分别为8个月（3 - 7个月至12 - 5个月）和12年8个月（6 - 4个月至16 - 8个月）。患者组的中位随访时间为3年（7 - 10年），对照组为4年1个月（1 - 10年）。SCA患儿的语言和表现智商（VIQ和PIQ）在时间1时显著低于对照组；另外，与MMS相关的PIQ有独立统计学意义的显著降低（p=0.004）。虽然通过第二次评估，与对照组相比，MMS患者的智商进一步显著下降，但在有和没有SCA的组之间，智商没有显著差异。虽然SCA导致的智商下降似乎并没有随着年龄的增长而变得更加明显，但患有和不患有MMS的人之间的差异与随着时间的推移而增加的影响有关。
Intelligence is reported to decline after onset of moyamoya in Japanese populations, but there is less evidence for this in Western populations where the condition may be secondary to stroke and sickle cell anaemia (SCA). Preoperative longitudinal IQ data were obtained from 15 children (seven males, eight females) who developed moyamoya syndrome (MMS) following a stroke (six with SCA, nine without SCA), and 19 controls (10 males, nine females; nine healthy control participants, 10 with SCA). At baseline assessment (Time 1) median. age of patients was 7 years 6 months (range 3y 7mo to 12y 5mo); median age of controls was 6 years 3 months (range 4y to 11y 6mo). At follow-up (Time 2), ages were 11 year;, 8 months (range 3y 7mo to 12y 5mo) and 12 years 8 months (range 6y 4mo to 16y 8mo) in patients and controls respectively. Median duration of follow-up for the patient group was 3 years (range 7 to 10y) and in controls, 4 years 1 month (range 1 to 10y). In children with SCA, Verbal and Performance IQs (VIQ and PIQ) were significantly lower than in controls at Time 1; there was an additional independent statistically significant reduction in PIQ associated with MMS (p=0.004). Although there were further significant reductions in IQ by the second assessment for patients with MMS compared with controls, IQ did not differ significantly between groups with and without SCA. While the reduction in IQ attributed to SCA does not appear to become more marked with increasing age, the difference between those with and without MMS is associated with increasing effect over time.