A galactoglucan isolated from of Cistanche deserticola Y. C. Ma. and its bioactivity on intestinal bacteria strains
A galactoglucan isolated from of Cistanche deserticola Y. C. Ma. and its bioactivity on intestinal bacteria strains
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从肉苁蓉 Y. C. Ma 中分离出的半乳葡聚糖。
DOI：
10.1016/j.carbpol.2019.115038
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发表时间：
2019
影响因子：
11.2
通讯作者：
Ding Kan
中科院分区：
文献类型：
--
作者：
Zeng Hui;Huang Lulin;Zhou Lishuang;Wang Peipei;Chen Xia;Ding Kan
为了了解多糖是否对肠道菌群有影响，我们从肉苁蓉中提取了平均分子量为7.96 kDa的中性多糖CDA-0.05。马。单糖组成分析表明，CDA-0.05由葡萄糖和半乳糖组成，摩尔比为96.4:3.6。da -0.05的主链含有1,4 -链α-D-Glcp、1,4,6 -链α-D-Glcp和1,4 -链β-D-Galp，而t -链α-D-Glcp的分支连接在1,4,6 -链α- d - gl葡聚糖的C-6上。生物活性试验结果表明，CDA-0.05能显著促进三种拟杆菌（B. thetaiotaomicron、B. ovatus和B. fragilis）的生长。此外，CDA-0.05还能促进干酪乳杆菌、植物乳杆菌和罗伊氏乳杆菌等益生菌的生长。这些结果表明，CDA-0.05可能有助于维持肠道内稳态，可以作为纤维或候选药物的一部分，通过调节肠道细菌对人体有益。
To understand whether polysaccharides may have impact on gut microbiota, a neutral polysaccharide CDA-0.05 with an average molecular weight of 7.96 kDa was obtained fromCistanche deserticolaY. C. Ma. The monosaccharide composition analysis indicated that CDA-0.05 was composed of glucose and galactose in a molar ratio of 96.4: 3.6. The backbone of CDA-0.05 contained 1, 4-linked α-D-Glcp, 1, 4, 6-linked α-D-Glcpand 1, 4-linked β-D-Galp, with branches of T-linked α-D-Glcpattached at C-6 of 1, 4, 6-linked α-D-Glcpresidues. Bioactivity test results suggested that CDA-0.05 could promote the growth of three species ofBacteroides (B. thetaiotaomicron, B. ovatus and B. fragilis) significantly. Furthermore, CDA-0.05 could also promote some probiotics growth, such asLactobacillus casei,Lactobacillus plantarumandLactobacillus reuteri. These results suggested that CDA-0.05 might help to maintain intestinal homeostasis and could be recommended as part of fibers or drugs candidate to benefit human body by regulating gut bacteria.