Mitochondrial cytochrome c biogenesis: no longer an enigma.
Mitochondrial cytochrome c biogenesis: no longer an enigma.
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DOI：
10.1016/j.tibs.2015.05.006
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发表时间：
2015-08
影响因子：
13.8
通讯作者：
Kranz RG
中科院分区：
文献类型：
--
作者：
Babbitt SE;Sutherland MC;San Francisco B;Mendez DL;Kranz RG
细胞色素c和c1是血红素蛋白，对有氧呼吸是必需的。线粒体释放细胞色素c是细胞凋亡启动的重要信号。C型细胞色素的生物发生涉及血红素与脱辅基细胞色素中的两个半胱氨酸（在保守的CXXCH序列处）的共价连接。血红素附着在大多数线粒体中由全细胞色素c合成酶（HCCS）催化，这也是输入脱辅基细胞色素c所必需的。因此，HCCS影响细胞色素c的细胞水平，影响线粒体生理学和细胞死亡。本文综述了HCCS的功能机制以及血红素和CXXCH基序中残基的作用。此外，我们认为出现在两个原核细胞色素c生物合成途径的概念。
Cytochromes c and c1are heme proteins that are essential for aerobic respiration. Release of cytochrome c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS), which is also necessary for import of apocytochrome c. Thus, HCCS affects cellular levels of cytochrome c, impacting mitochondrial physiology and cell death. Here, we review the mechanisms of HCCS function and the roles played by heme and residues in the CXXCH motif. Additionally, we consider concepts emerging within the two prokaryotic cytochrome c biogenesis pathways.