The human inferior parietal cortex: Cytoarchitectonic parcellation and interindividual variability
The human inferior parietal cortex: Cytoarchitectonic parcellation and interindividual variability
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DOI：
10.1016/j.neuroimage.2006.06.054
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发表时间：
2006-11-01
期刊：
影响因子：
5.7
通讯作者：
Zilles, Karl
中科院分区：
文献类型：
--
作者：
Caspers, Svenja;Geyer, Stefan;Zilles, Karl
下顶叶皮层（IPC）整合来自不同感觉方式的信息，并在各种高级认知功能中发挥重要作用。 Brodmann (Brodmann, K., 1909. Vergleichende Lokalizeslehre der GroBhirnrinde. Barth, Leipzig) 提出将 IPC 的细胞结构细分为仅两个皮质区域：吻侧 (BA 40) 和尾侧 (BA 39) 区域。尽管他的方案一再受到其他观察者的挑战，但它仍然用于功能成像数据的解剖定位。所有这些细胞和骨髓结构图之间的明显差异可能部分是由于通过组织学切片的纯粹目视检查来定义细胞结构边界的观察者依赖程序引起的，部分是由于细胞结构的个体间变异性引起的。目前的观察结果和由此产生的 IPC 皮质图是基于细胞结构边界的定量、独立于观察者的定义，并考虑到大脑中每个区域的地形变异性。在组织学处理之前，使用 MRI 3-D FLASH 序列对 10 个人类死后大脑进行扫描。石蜡包埋后，制备全脑的连续切片，并对切片进行细胞体染色。对包含 IPC 的切片进行高分辨率数字化后，我们使用层状细胞密度分布的多元统计分析来定义该大脑区域的每个皮质区域的细胞结构和边界。与之前的观察相反，我们在 IPC 中发现了 7 个细胞结构区域：5 个位于喙部（覆盖 BA 40 区域），2 个位于尾部（覆盖 BA 39 区域）。我们观察到每个区域的地形存在相当大的个体差异。未发现宏观解剖标志和细胞结构边界之间一致的对应关系。这种新的人类 IPC 细胞结构图显示了皮质微观结构的区域差异，这表明了功能分化。此外，该图在三个维度上进行记录，从而为解释功能成像研究提供了强大的解剖学基础。 (c) 2006 Elsevier Inc. 保留所有权利。
The inferior parietal cortex (IPC) integrates information from different sensory modalities and plays an important role in a variety of higher cognitive functions. Brodmann (Brodmann, K., 1909. Vergleichende Lokalisationslehre der GroBhirnrinde. Barth, Leipzig) proposed a cytoarchitectonic subdivision of the IPC into only two cortical areas, a rostral (BA 40) and a caudal (BA 39) area. Although his scheme was repeatedly challenged by other observers, it is still used for the anatomical localization of functional imaging data. The apparent differences between all these cyto- and myeloarchitectonic maps may be caused partly by the observer-dependent procedure of defining cytoarchitectonic borders by pure visual inspection of histological sections and partly by the interindividual variability of cytoarchitecture. The present observations and the resulting cortical map of the IPC are based on quantitative, observer-independent definitions of cytoarchitectonic borders and take into account each area's topographical variability across brains. Ten human postmortem brains were scanned using an MRI 3-D FLASH sequence prior to histological processing. After embedding in paraffin, serial sections through whole brains were prepared, and the sections were stained for cell bodies. Following high-resolution digitization of sections containing the IPC, we defined the cytoarchitecture and borders of each cortical area of this brain region using a multivariate statistical analysis of laminar cell density profiles. In contrast to previous observations, we found seven cytoarchitectonic areas in the IPC: five in the rostral (covering the region of BA 40) and two in the caudal part (covering the region of BA 39). We observed considerable interindividual variability in the topography of each area. A consistent correspondence between macroanatomical landmarks and cytoarchitectonic borders was not found. This new cytoarchitectonic map of the human IPC demonstrates regional differences in the cortical microstructure that is suggestive of functional differentiation. Furthermore, the map is registered in three dimensions and thereby provides a robust anatomical base for interpreting functional imaging studies. (c) 2006 Elsevier Inc. All rights reserved.