Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine
Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine
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DOI：
10.1016/j.vaccine.2003.07.004
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发表时间：
2004-01-02
期刊：
影响因子：
5.5
通讯作者：
Andrews, GP
中科院分区：
文献类型：
--
作者：
Little, SF;Ivins, BE;Andrews, GP
在这些研究中，在新西兰白色（NZW）兔中鉴定了抗炭疽保护的血清学相关性，这些兔已经注射了一次或两次不同量的重组保护性抗原（rPA）和氢氧化铝佐剂（Alhydrogel）。随后通过气溶胶途径用炭疽芽孢杆菌艾姆斯分离株的孢子对家兔进行攻毒。结果表明，通过定量抗rPA IgG ELISA和毒素中和抗体（TNA）测定的抗体应答是对A B的保护作用的显著预测因子（P < 0.0015）。炭疽菌气溶胶孢子攻击。爱思唯尔有限公司出版
In these studies, a serological correlate of protection against anthrax was identified in New Zealand white (NZW) rabbits that had been given one or two injections of various amounts of recombinant protective antigen (rPA) combined with aluminum hydroxide adjuvant (Alhydrogel). Rabbits were subsequently challenged by the aerosol route with spores of the Ames isolate of Bacillus anthracis. Results suggested that the antibody response, as determined by the quantitative anti-rPA IgG ELISA and toxin neutralizing antibody (TNA) assay, were significant predictors (P < 0.0015) of protection against a B. anthracis aerosol spore challenge in rabbits. Published by Elsevier Ltd.