Antibody to dengue 1 detected more than 6 years after infection
Antibody to dengue 1 detected more than 6 years after infection
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DOI：
10.1089/vim.2007.0050
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发表时间：
2007-12-01
期刊：
影响因子：
2.2
通讯作者：
Effler, Paul
中科院分区：
文献类型：
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作者：
Imrie, Allison;Meeks, Janet;Effler, Paul
我们调查了那些回忆起在第二次世界大战期间经历过类似登革热疾病的个体对登革热病毒感染的不道德反应的持续时间，当时登革热流行在整个太平洋和东南亚地区发生。 1943 年 7 月，时隔 31 年登革热在夏威夷再次出现。在接下来的 12 个月内，共报告了 1495 例本地传播病例，并确定了至少 46 例输入性病例，其中大多数是从太平洋战区返回的军人。 2005 年（即症状出现 60 多年后）收集的血清样本使用快速 ELISA 测试和空斑减少中和测试来检测是否存在登革热特异性抗体。七个样本中的四个呈登革热特异性 IgG 阳性，并且对登革热 1 的中和滴度 >= 160。我们描述了 60 多年前感染者的血清中存在登革热特异性抗体。
We investigated the duration of Immoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following an interval of 31 years. Over the next 12 months a total of 1495 locally transmitted cases were reported, and at least 46 imported cases were identified, most of which were among members of the military returning from the Pacific Theatre of the war. Serum samples collected in 2005, more than 60 years after onset of symptoms, were tested for the presence of dengue-specific antibodies using a rapid ELISA test, and by plaque reduction neutralization test. Four of seven samples were positive for dengue-specific IgG and demonstrated neutralization titers >= 160 to dengue 1. We describe the existence of dengue-specific antibodies in the serum of people infected more than 60 years earlier.