Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes
Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes
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DOI：
10.1016/j.atherosclerosis.2006.03.005
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发表时间：
2007-03-01
期刊：
影响因子：
5.3
通讯作者：
Kawamori, Ryuzo
中科院分区：
文献类型：
--
作者：
Mita, Tomoya;Watada, Hirotaka;Kawamori, Ryuzo
为了研究高纯度二十碳五烯酸（EPA）对糖尿病大血管病变进展的影响，我们进行了一项开放标签随机前瞻性试验。81例日本2型糖尿病患者被随机分为EPA （1800 mg/天）治疗组和对照组。观察两组患者治疗前后颈动脉内膜-中膜厚度（IMT）和肱-踝脉波速度（baPWV）。60例患者（EPA组，n = 30；对照组，n = 30）完成了本研究。在2.1 +/- 0.2年的研究期间，EPA处理组的平均IMT和最大IMT与对照组相比逐年显著下降(平均IMT为-0.029 +/- 0。112 mm vs 0.016 +/- 0.109 mm, P = 0.029；最大IMT分别为-0.084 +/- 0.113 mm和-0.005 +/- 0.108 mm, P = 0.0008)。与对照组相比，EPA处理组的baPWV也有显著改善（分别为-22.1 +/- 127.9 cm/s和62.3 +/- 223 cm/s, P = 0.021）。多元回归分析显示，EPA的使用是与年平均IMT改善相关的显著独立因素（R-2 = 0.067）。综上所述，这是首次证明纯化EPA可改善2型糖尿病患者颈动脉IMT和baPWV。2006爱思唯尔爱尔兰有限公司版权所有。
To investigate the effect of highly purified eicosapentaenoic acid (EPA) on the progression of diabetic macroangiopathy, we performed an open-label randomized prospective trial. A total of 81 Japanese type 2 diabetes were randomly assigned to the EPA (1800 mg/day) treated group or the control group. Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were evaluated before and after treatment in both groups. Sixty patients (EPA group, n = 30; control group, n = 30) completed this study. During the study period of 2.1 +/- 0.2 years, the mean IMT and max IMT of the EPA treated group showed a significant annual decrease compared with that of the control group (mean IMT, -0.029 +/- 0. 112 mm versus 0.016 +/- 0.109 mm, respectively, P = 0.029; max IMT, -0.084 +/- 0.113 mm versus -0.005 +/- 0.108 mm, respectively, P = 0.0008). The baPWV was also improved significantly in the EPA treated group compared with the control group (-22.1 +/- 127.9 cm/s versus 62.3 +/- 223 cm/s, respectively, P = 0.021). Multiple regression analysis showed that the administration of EPA was a significant and independent factor associated with an annual improvement of mean IMT (R-2 = 0.067). In summary, this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with type 2 diabetes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.