Molecular Pathogenesis of Vibrio vulnificus.
Molecular Pathogenesis of Vibrio vulnificus.
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DOI：
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发表时间：
2005-02
影响因子：
3
通讯作者：
P. Gulig;Keri L. Bourdage;Angela M. Starks
中科院分区：
文献类型：
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作者：
P. Gulig;Keri L. Bourdage;Angela M. Starks
创伤弧菌是人类的一种机会性病原体，具有引起罕见但毁灭性疾病的能力。这种细菌自然存在于河口环境中，经常污染海产品。在食用未煮熟的、受污染的海鲜几天内，易感人群可能会死于败血症。此外，在健康人群中，创伤弧菌引起伤口感染，可能需要截肢或导致败血症。这些疾病的共同特点是细菌在宿主组织中繁殖极快并造成广泛损害。尽管使用动物和细胞培养模型对其毒力进行了20多年的分析，但令人惊讶的是，人们对创伤弧菌致病的机制知之甚少。这在一定程度上是因为在动物模型中观察到的细菌感染与注射毒素的差异。然而，越来越多的遗传分析与详细的动物模型相结合，揭示了创伤弧菌病发病机制的新见解。
Vibrio vulnificus is an opportunistic pathogen of humans that has the capability of causing rare, yet devastating disease. The bacteria are naturally present in estuarine environments and frequently contaminate seafoods. Within days of consuming uncooked, contaminated seafood, predisposed individuals can succumb to sepsis. Additionally, in otherwise healthy people, V. vulnificus causes wound infection that can require amputation or lead to sepsis. These diseases share the characteristics that the bacteria multiply extremely rapidly in host tissues and cause extensive damage. Despite the analysis of virulence for over 20 years using a combination of animal and cell culture models, surprisingly little is known about the mechanisms by which V. vulnificus causes disease. This is in part because of differences observed using animal models that involve infection with bacteria versus injection of toxins. However, the increasing use of genetic analysis coupled with detailed animal models is revealing new insight into the pathogenesis of V. vulnificus disease.