Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential.
Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential.
复制标题
缺血性中风中 Apelin/Apelin 受体的时间表达及其治疗潜力。
DOI：
10.3389/fnmol.2017.00001
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发表时间：
2017
影响因子：
4.8
通讯作者：
Bai B
中科院分区：
文献类型：
--
作者：
Wu Y;Wang X;Zhou X;Cheng B;Li G;Bai B
中风是全球死亡和残疾的主要原因之一，缺血性中风约占病例的87%。改善中风后的康复是中风治疗中的一项重大挑战。积累的证据表明，由阿佩林（apelin）和阿佩林受体（APLNR）组成的阿佩林能系统在缺血性中风中存在暂时的失调。此外，阿佩林能系统通过各种分子途径抑制神经元凋亡和促进血管生成，在中风后康复中起着关键作用。在这篇综述文章中，我们总结了阿佩林和APLNR在缺血性中风中的时间表达及其失调机制。此外，还讨论了阿佩林能系统在缺血性中风中的保护作用及其保护作用的潜在机制。进一步地，也将讨论激活阿佩林能系统作为一种潜在疗法的关键问题。这篇综述文章的目的是阐明利用激活阿佩林能系统来治疗缺血性中风。
Stroke is one of the leading causes of death and disability worldwide, and ischemic stroke accounts for approximately 87% of cases. Improving post-stroke recovery is a major challenge in stroke treatment. Accumulated evidence indicates that the apelinergic system, consisting of apelin and apelin receptor (APLNR), is temporally dysregulated in ischemic stroke. Moreover, the apelinergic system plays a pivotal role in post-stroke recovery by inhibiting neuronal apoptosis and facilitating angiogenesis through various molecular pathways. In this review article, we summarize the temporal expression of apelin and APLNR in ischemic stroke and the mechanisms of their dysregulation. In addition, the protective role of the apelinergic system in ischemic stroke and the underlying mechanisms of its protective effects are discussed. Furthermore, critical issues in activating the apelinergic system as a potential therapy will also be discussed. The aim of this review article is to shed light on exploiting the activation of the apelinergic system to treat ischemic stroke.