Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster. II. Residual effects on the adult cerebellum.
Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster. II. Residual effects on the adult cerebellum.
复制标题
子宫内甲基汞暴露对金仓鼠小脑的病理影响。
DOI：
10.1016/0013-9351(81)90206-1
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发表时间：
1981
影响因子：
8.3
通讯作者：
J. Townsend
中科院分区：
文献类型：
--
作者：
K. Reuhl;L. Chang;J. Townsend
在金仓鼠 (Mesocricetus auratus) 中研究了产前甲基汞暴露的长期影响。怀孕动物在妊娠第 10 天给予 10 毫克/公斤甲基汞，或在妊娠第 10-15 天给予 2 毫克/公斤甲基汞。来自处理组和对照组的动物在成年时被处死，并通过光学和电子显微镜检查小脑。在治疗动物的分子层中观察到星形胶质细胞增生的焦点区域。在颗粒和浦肯野神经元的核周和树突中观察到先前损伤的后遗症，主要特征是大量残留体。观察到有髓轴突的退行性变化。讨论了产前暴露动物中持续神经元变性的可能假设。
The long-term effects of prenatal methylmercury exposure were studied in the golden hamster (Mesocricetus auratus). Pregnant animals were given either 10 mg/kg methylmercury on gestational day 10 or 2 mg/kg on gestational days 10–15. Animals from treated and control litters were sacrificed as adults and cerebella examined by light and electron microscopy. Focal areas of astrogliosis were observed in the molecular layer of treated animals. Sequellae of previous injury, characterized primarily by abundant residual bodies, were observed in the perikarya and dendrites of granule and Purkinje neurons. Degenerative change of myelinated axons was observed. Possible hypotheses for continued neuronal degeneration in prenatally exposed animals are discussed.