Immunologic responses to vaccinia vaccines administered by different parenteral routes
Immunologic responses to vaccinia vaccines administered by different parenteral routes
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DOI：
10.1086/513968
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发表时间：
1997-04-01
影响因子：
6.4
通讯作者：
Graham, JA
中科院分区：
文献类型：
--
作者：
McClain, DJ;Harrison, S;Graham, JA
为了开发一种反应原性较低但免疫原性相同的疫苗，本研究对91名人类志愿者进行了一项新的细胞培养衍生的牛痘病毒疫苗的安全性和免疫原性效力的比较，皮内和肌内接种的牛痘疫苗与通过划痕接种的许可牛痘疫苗，划痕接种者中发生皮肤痘病变的比例较高。皮内接种和皮内接种发生皮肤痘病变的接种者有更多的局部反应，但也比未发生皮肤痘病变的接种者获得了显著更高的细胞介导和中和抗体应答。虽然反应原性较低，但皮内或肌内接种牛痘疫苗而不伴随皮肤痘病变的发生诱导了较低的免疫应答。
To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification, Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions, Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses.