Chinese American and Non-Hispanic White Breast Cancer Patients' Knowledge and Use of BRCA Testing.
Chinese American and Non-Hispanic White Breast Cancer Patients' Knowledge and Use of BRCA Testing.
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DOI：
10.3390/ijerph20043384
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发表时间：
2023-02-15
影响因子：
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通讯作者：
Wang, Judy Huei-Yu
中科院分区：
文献类型：
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作者：
Wang, Haocen;Chen, Lei-Shih;Hsiao, Hsin-Yi;Hsiao, Suh Chen;Han, Tian;Chang, Emily;Assoumou, Bertille;Wang, Judy Huei-Yu
乳腺癌是华裔美国女性中最常诊断出的癌症。了解 BRCA1 和 BRCA2 (BRCA1/2) 基因突变状态可以指导针对性治疗预防乳腺癌复发和其他 BRCA 相关癌症，从而改善乳腺癌患者的健康结果。然而，目前尚不清楚美籍华人乳腺癌患者对 BRCA 检测的了解和使用是否存在差异。这项横断面研究调查了美籍华人和非西班牙裔白人 (NHW) 乳腺癌患者在 BRCA 检测知识和使用方面可能存在的差异。我们通过电话采访的方式对过去两年内被诊断患有乳腺癌的 45 名华裔美国人和 48 名 NHW 成年乳腺癌患者进行了调查。结果显示，种族与 BRCA 检测的使用没有统计学相关性。 BRCA 检测的利用率与家族史 (p < 0.05) 和年龄 (p < 0.05) 相关。然而，华裔美国参与者对 BRCA 检测的理解明显低于 NHW 参与者 (p = 0.030)。我们的研究结果表明，美国华裔乳腺癌患者和非健康女性乳腺癌患者之间的 BRCA 检测知识存在差异。需要进行遗传教育和咨询来提高华裔乳腺癌患者对 BRCA 检测的了解和接受程度。
Breast cancer is the most commonly diagnosed cancer among Chinese American women. Knowing the BRCA1 and BRCA2 (BRCA1/2) gene mutation status can improve breast cancer patients’ health outcomes by guiding targeted treatment towards preventing breast cancer recurrence and other BRCA-related cancers. Nevertheless, it is unclear if there is a disparity in knowledge and use of BRCA testing among Chinese American breast cancer patients. This cross-sectional study investigated the possible presence of differences in the knowledge and the use of BRCA testing between Chinese American and Non-Hispanic White (NHW) breast cancer patients. We surveyed 45 Chinese American and 48 NHW adult breast cancer patients who had been diagnosed with breast cancer within the previous two years through telephone interviews. The results showed that race was not statistically related to the use of BRCA testing. BRCA testing utilization was associated with family history (p < 0.05) and age (p < 0.05). However, Chinese American participants’ understanding of BRCA testing was significantly lower than that of NHW participants (p = 0.030). Our findings suggest that a disparity exists in BRCA testing knowledge between Chinese American and NHW breast cancer patients. Genetic education and counseling are needed to improve BRCA testing knowledge and uptake among Chinese American breast cancer patients.