Physical fitness, endurance training, and the growth hormone insulin-like growth factor I system in adolescent females
Physical fitness, endurance training, and the growth hormone insulin-like growth factor I system in adolescent females
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DOI：
10.1210/jc.81.11.3986
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发表时间：
1996-11-01
影响因子：
5.8
通讯作者：
Cooper, DM
中科院分区：
文献类型：
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作者：
Eliakim, A;Brasel, JA;Cooper, DM
我们研究了身体健康与 GH-胰岛素样生长因子 I (IGF-I) 系统循环成分之间的关系 [即青春期女性（年龄范围，15-17 岁）中的 GH、GH 结合蛋白 (GHBP)、IGF-I 和 IGF 结合蛋白 1-5（IGFBP-1 至 -5）]。该研究包括 1) 一项横断面方案 (n = 23)，其中 GH-IGF-I 成分与健康相关，根据大腿肌肉体积和最大 O-2 摄取量进行估计； 2) 一项前瞻性研究，在为期 5 周的耐力型训练之前和之后检查体能、GH-IGF-I 系统成分和骨钙素（对照，n = 6；训练者，n = 10）。横断面分析显示，健康度与 1) 平均 12 小时过夜 GH 水平、2) GHBP 和 3) IGF-I 之间存在显着 (P < 0.05) 正相关。肌肉体积与IGFBP-2和-4呈负相关。前瞻性训练研究与 1) 循环骨钙素增加 (39 +/- 14%；P < 0.007) 和 2) IGF-I (-14 +/- 5%；P < 0.05) 和 IGFBP-5 (-10 +/- 4%；P < 0.04) 减少相关。出乎意料的是，IGFBP-3 在对照组（-8 +/- 2%；P < 0.01）和受过训练的受试者（-5 +/- 3%；P < 0.05）中均下降，而 GHBP 仅在对照组中降低（-10 +/- 7%；P < 0.04）。 总之，身体健康的青春期女孩的平均血清 GH、GHBP 和 IGF-I 往往会升高。相反，短暂的耐力训练会导致肌肉质量和血清骨钙素的增加，但不会伴随 GH 或 IGF-I 的增加。事实上，训练可能在短期内导致激素分解代谢状态，表现为 IGF-I 和 IGFBP-5 的减少。
We examined the relationship between physical fitness and circulating components of the GH-insulin-like growth factor I (IGF-I) system [i.e. GH, GH-binding protein (GHBP), IGF-I, and IGF-binding proteins 1-5 (IGFBP-1 through -5)] in adolescent females (age range, 15-17 yr). The study consisted of 1) a cross-sectional protocol (n = 23) in which GH-IGF-I components were correlated with fitness, as estimated by thigh muscle volume and maximal O-2 uptake; and 2) a prospective study in which fitness, GH-IGF-I system components, and osteocalcin were examined before and after a 5-week period of en durance-type training (control, n = 6; trained, n = 10). The cross-sectional analysis revealed significant (P < 0.05) positive correlations between fitness and 1) mean 12-h overnight GH levels, 2) GHBP, and 3) IGF-I. Muscle volume was negatively correlated with both IGFBP-2 and -4. The prospective training study was associated with 1) increases in circulating osteocalcin (39 +/- 14%; P < 0.007), and 2) decreases in IGF-I (-14 +/- 5%; P < 0.05) and IGFBP-5 (-10 +/- 4%;P < 0.04). Unexpectedly, IGFBP-3 fell in both control (-8 +/- 2%; P < 0.01) and trained subjects (-5 +/- 3%; P < 0.05), and GHBP was reduced only among control subjects (-10 +/- 7%; P < 0.04).In summary, fitter adolescent girls tended to have increased mean serum GH, GHBP, and IGF-I. In contrast, brief endurance training led to increases in muscle mass and serum osteocalcin that were not accompanied by increases in GH or IGF-I. In fact, training may, in the short term, have led to a catabolic state hormonally expressed by reductions in IGF-I and IGFBP-5.