Herpes virus in Alzheimer's disease: relation to progression of the disease
Herpes virus in Alzheimer's disease: relation to progression of the disease
复制标题
DOI：
10.1016/j.neurobiolaging.2013.06.024
复制
发表时间：
2014-01-01
影响因子：
4.2
通讯作者：
Licastro, Federico
中科院分区：
文献类型：
--
作者：
Carbone, Ilaria;Lazzarotto, Tiziana;Licastro, Federico
关于疱疹家族的不同病毒，如巨细胞病毒（CMV）、EB病毒（EBV）或人类疱疹病毒6（HHV-6）在阿尔茨海默病（AD）中的研究很少。分析来自外周血白细胞（PBL）和脑样品的DNA是否存在CMV、EBV或HHV-6。所有样本均为CMV阴性。在AD脑中，EBV阳性率为6%，而AD患者的PBL样本中有45%和对照组中有31%为EBV阳性（p = 0.05）。HHV-6在AD的PBL样品中显示出23%的阳性，在对照中显示出4%的阳性（p = 0.002）。17%的AD脑组织HHV-6阳性。在一组老年人中，随访5年，EBV阳性或HHV-6阳性PBL在发展为临床AD的患者中增加。病毒血清学阳性也进行了调查，CMV和EBV抗原的IgG水平也增加了在随访期间发展AD的受试者。我们的研究结果表明，EBV和HHV-6可能是老年人认知功能恶化和进展为AD的环境危险因素。(c)2014爱思唯尔公司All rights reserved.
Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA from peripheral blood leukocytes (PBL) and brain samples were analyzed for the presence of CMV, EBV, or HHV-6. All samples were negative for CMV. EBV positivity was 6% in AD brains, whereas 45% of PBL samples from AD patients and 31% from controls were positive for EBV (p = 0.05). HHV-6 showed a 23% positivity in PBL samples from AD and 4% from controls (p = 0.002). 17% of AD brains were HHV-6 positive. Within a group of elderly individuals, followed up for 5 years, EBV-positive or HHV-6-positive PBL increased in those who developed clinical AD. Virus serological positivity was also investigated, and IgG levels for CMV and EBV antigens were also increased in those subjects who developed AD during the follow-up. Our findings suggest that EBV and HHV-6 may be environmental risk factors for cognitive deterioration and progression to AD in elderly persons. (c) 2014 Elsevier Inc. All rights reserved.