Intact hedonic responses to sweet tastes in autism spectrum disorder
Intact hedonic responses to sweet tastes in autism spectrum disorder
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DOI：
10.1016/j.rasd.2013.12.003
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发表时间：
2014-03-01
影响因子：
2.5
通讯作者：
Dichter, Gabriel S.
中科院分区：
文献类型：
--
作者：
Damiano, Cara R.;Aloi, Joseph;Dichter, Gabriel S.
甜味测试 (STT) 是一项标准化测量，旨在衡量检测甜味差异（甜味敏感性）和对甜味的享乐反应（甜味喜好）的能力。 STT 的反应概况表明，以奖励处理系统功能失调为特征的精神疾病（包括暴食症和物质使用障碍）对甜味的享乐反应增强，而控制 STT 反应的一个推定机制是大脑阿片类药物系统。本研究检查了 20 名患有自闭症谱系障碍 (ASD) 的成年人和 38 名健康对照成年人的 STT 反应。自闭症谱系障碍组和对照组之间的甜味敏感性或对甜味的享乐反应没有差异。在自闭症谱系障碍样本中，自闭症谱系障碍症状的严重程度与甜味敏感性相关，但与对甜味的享乐反应无关。结果可能最终揭示大脑阿片类药物系统在自闭症谱系障碍中的功能。 (C) 2013 Elsevier Ltd. 保留所有权利。
The Sweet Taste Test (STT) is a standardized measure designed to index the ability to detect differences in sweet tastes (sweet taste sensitivity) and hedonic responses to sweet tastes (sweet taste liking). Profiles of response on the STT suggest enhanced hedonic responses to sweet tastes in psychiatric disorders characterized by dysfunctional reward processing systems, including binge-eating disorders and substance use disorders, and a putative mechanism governing STT responses is the brain opioid system. The present study examined STT responses in 20 adults with autism spectrum disorder (ASD) and 38 healthy control adults. There were no differences in sweet taste sensitivity or hedonic response to sweet tastes between the ASD and control groups. Within the ASD sample, ASD symptom severity was associated with sweet taste sensitivity, but not hedonic response to sweet taste. Results may ultimately shed light on brain opioid system functioning in ASD. (C) 2013 Elsevier Ltd. All rights reserved.