Pharmacokinetics and applications of magnetic nanoparticles.
Pharmacokinetics and applications of magnetic nanoparticles.
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DOI：
10.2174/138920021131400109
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发表时间：
2013-09
影响因子：
2.3
通讯作者：
Runyi Mao;Jing Wang;Jiao Pei;Songtao Wu;Jie Feng;Yunfeng Lin;Xiaoxiao Cai
中科院分区：
文献类型：
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作者：
Runyi Mao;Jing Wang;Jiao Pei;Songtao Wu;Jie Feng;Yunfeng Lin;Xiaoxiao Cai
纳米材料在生物医学应用方面具有巨大的潜力，而目前正在研究的一些最有前途的纳米材料显示出长期的组织保留并含有重金属。本文研究了磁性纳米颗粒（MNP）的药代动力学，以帮助确定具有最佳药代动力学和清除率的有前途的候选物，用于生物医学用途，并合成理想的生物医学用途的纳米材料。术语“磁性纳米颗粒”（MNP）是指具有铁磁性的纳米颗粒。这样的纳米颗粒具有特殊的特性，并且在生物领域中的许多领域已经进行了研究，例如，固定化酶和蛋白质、生物细胞、大分子分离、药物载体和靶向免疫生物传感器。
Nanomaterials possess enormous potential for biomedical applications, while some of the most promising nanomaterials currently under investigation demonstrate prolonged tissue retention and contain heavy metals. This article investigates the pharmacokinetics of magnetic nanoparticles (MNPs) to help identify promising candidates with optimal pharmacokinetics and clearance from the body for biomedical use and synthesize nanomaterials ideal for biomedical use. The term 'magnetic nanoparticles' (MNPs) refers to nanoparticles with ferromagnetism. Such nanoparticles have special characteristics, and many in the field of biological field have undertaken research involving, e.g., immobilized enzymes and proteins, biological cells, macromolecular separation, drug carriers, and targeted, immune, biological sensors.