POTENTIAL THERAPEUTIC INITIATIVES FOR FIBROGENIC LUNG-DISEASES
POTENTIAL THERAPEUTIC INITIATIVES FOR FIBROGENIC LUNG-DISEASES
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DOI：
10.1378/chest.108.3.848
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发表时间：
1995-09-01
期刊：
影响因子：
9.6
通讯作者：
FINE, A
中科院分区：
文献类型：
--
作者：
GOLDSTEIN, RH;FINE, A
影响肺和其他组织的纤维化过程的特征在于刺激成纤维细胞增殖和结缔组织沉积。由糖皮质激素或细胞毒性剂组成的常规疗法在阻断疾病进展方面通常是无效的。潜在的新疗法已经从肺纤维化的动物模型的使用和炎症反应的细胞和分子生物学的最新进展中出现。这种疗法涉及使用针对某些生长因子、细胞因子、或在纤维化反应过程中产生的氧化剂。在这篇文章中，我们回顾了这些进展可能的治疗应用。
Fibrotic process affecting the lung and other tissues is characterized by stimulation of fibroblast proliferation and connective tissue deposition. Conventional therapy consisting of glucocorticoids or cytotoxic agents is usually ineffective in blocking progression of disease, Potential new therapies have emerged from the use of animal models of pulmonary fibrosis and recent advances in the cellular and molecular biology of inflammatory reactions, Such therapies involve the use of substances directed against the action of certain growth factors, cytokines, or oxidants that are elaborated during the fibrotic reaction. In this article, we review possible therapeutic applications of these advances.