Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System
Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System
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DOI：
10.1002/anie.201002221
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Toth, Istvan
中科院分区：
文献类型：
--
作者：
Skwarczynski, Mariusz;Zaman, Mehfuz;Toth, Istvan
Infection with group A streptococci (Streptococcus pyogenes, GAS), which is one of the most common and widespread human pathogens, can result in a broad range of diseases, including pharyngitis, with the potential of acute and postinfectious rheumatic fever (ARF) and rheumatic heart disease (RHD).[1] It is estimated that GAS infection is responsible for over half a million deaths per year worldwide.[2] The inability to effectively control GAS infections with antibiotics [3] has prompted extensive research into the development of a vaccine against this infection. However, to date, no prophylactic GAS vaccine is available on the market. Immunity to GAS relies on the production of opsonic antibodies specific to the hypervariable N-terminal and conserved C-terminal regions of the coiled-coil α-helical surface Mprotein, which is the major virulent factor in GAS.[1, 4] The development of an effective vaccine for GAS has been challenged by induced autoimmunity from epitopes derived from the C-terminal regions.[5] The minimal B-cell epitopes are believed to be safe but showed little or no immunogenicity.[6]It was recently hypothesized that self-assembled amphiphilic polymers can serve as nanoscale delivery systems for subunit vaccines, but no proof of concept has been demonstrated.[7] We report herein a polymer-based vaccine delivery system that offers several potential advantages over previously reported strategies. It was expected that 1) an amphiphilic structure can self-assemble to produce particles with the desired size, 2) the hydrophobic polymer ensures pre-
